BoZo Research Center Inc.

BoZo Research Center Inc. supports optimizing lead compounds.
This page provides a detailed overview of their non-clinical study capabilities, examples of disease models, and case studies.
It serves as a useful reference when selecting a CRO(contract research organization).

Features of BoZo Research Center Inc.’s Non-Clinical Study Services

Comprehensive Development Support Platform

BoZo Research Center Inc. offers comprehensive non-clinical testing service for a wide range of drug development projects, including in pharmaceuticals, agrochemicals, and food products.
Their service encompasses pharmacological, toxicological, and analytical studies by specialists in each field.
They provide consistent support from the early drug discovery phase to commercialization phase.

Extensive Testing Experience and Expertise

The center has a proven track record in providing non-clinical studies.They are especially recognized for their research in cancer and metabolic diseases, offering extensive in vivo and in vitro testing using various disease models.
Consulting services by the team of experts are also available.

Compliance with the 3R Principles

Non-clinical studies at BoZo Research Center Inc. are conducted with a strong commitment to animal welfare, following the 3R (Replacement, Reduction, and Refinement) principles.
The center is fully accredited by AAALAC International, and all of their facilities are compliant to GLP standards, which ensures that studies are performed in a safe and ethical environment.

Examples of Disease Models at BoZo Research Center Inc.

It is essential to go through the testing of candidate compounds in animal models that reproduce the target disease before advancing to clinical trials.

However, clinically relevant disease models may not always exist, thus there are demands for animal models with strong clinical correlation.

Below are some examples of disease models offered at Ina Research.

Allergic Rhinitis Model

Guinea pigs sensitized with OVA are used to evaluate drug effects on acute/chronic nasal reactions—such as rhinitis and nasal obstruction—induced by intranasal antigen administration, as well as on inflammatory cell infiltration in the nasal cavity.
Rats can also be used for efficacy studies on increased vascular permeability in the nasal mucosa.

Asthma Model

Guinea pigs sensitized with OVA are used to examine drug effects on acute/chronic asthmatic reactions and airway obstruction induced by antigen inhalation, as well as on inflammatory cell infiltration in the airway lumen.
Mouse models are also available to investigate airway hyperresponsiveness and airway remodeling.

Non-Clinical Study Case Examples

Respiratory System Studies

Pharmacological and medical device performance evaluations are also available by experienced researchers at BoZo Research Center Inc..
There are models for rhinitis, asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis.
For COPD evaluations, various pathological models are available, including tobacco solution administration models (guinea pigs) and tobacco smoke exposure models (mice, rats, and guinea pigs).

Company Information

BoZo Research Center Inc. provides tailored solutions that meet the needs of pharmaceutical companies, medical device manufacturers, academic institutions, bio-ventures, and medical organizations.