Non-Clinical CROs and Agencies
3 Recommended Contract Research Organizations for Non-Clinical Studies
— by Target goal and Expertise
In drug discovery, the quality and efficiency of non-clinical studies have a direct impact on clinical success rates, development costs, and overall length of time required in R&D.
In recent years, there has been more demand for clinically relevant data, globally accepted reliability, and accurate early-stage screening.
Thus, it is more important than ever to select the right CRO (Contract Research Organization) for strategic approach.
In this article, we highlight three CROs with proven technical capabilities, expertise, and long standing track records. These are our TOP 3 choices based on their capabilities and the specific target goals of the researchers for their non-clinical studies.
Pharmacology (Efficacy) Studies
Replicate unknown pathological models and
Discovery to clinically oriented drug evaluation
SMC Laboratories, Inc.
Reference: SMC Laboratories, Inc. official website (https://www.smccro-lab.com/jp/)
Why SMC Laboratories, Inc.
SMC Laboratories, Inc. has established a disease models using patented mouse technologies.
The company has established proprietary pathological models—particularly in liver disease and fibrosis—and continues to expand their approach across a wide range of models in cancer, inflammation, and metabolic diseases.
From exploratory research to clinically oriented efficacy evaluation, SMC offers customized study designs, dosing strategies, and evaluation analysis tailored to each project.
Their collaborative approachallows researchers to discuss and refine study plans together with SMC’s expert scientists.
With flexible small-scale study options and strong technical support, SMC Laboratories, Inc. is an ideal partner for start-ups, biotech ventures, and academic institutions alike.
Safety Studies
Comprehensive Safety Evaluation for FIH Applications
Labcorp Holdings Inc.
(Labcorp Drug Development)
Reference: Labcorp Holdings Inc. official website (https://jp.labcorp.com/)
Why Labcorp Holdings Inc.
Labcorp Holdings Inc. provides a fully integrated GLP testing system aligned with international regulatory standards, including FDA, EMA, and PMDA requirements.
All studies are conducted under ICH-compliant quality assurance, making it ready for data submission.
The company has extensive expertise in long-term toxicity studies such as Segment I–III reproductive and carcinogenicity studies, as well as 2-year chronic toxicity assessments.
Labcorp Holdings Inc.’s comprehensive approach enables sponsors to efficiently outsource the entire preclinical package from toxicology, toxicokinetic (TK), and safety pharmacology study design to execution. This accelerates a path to First-in-Human (FIH) trials.
For most of the global drug developers, this all-in-one service structure minimizes cost, risk, and expedite the time before advancing to clinical phase.
Pharmacokinetic (PK/PD) Studies
High-Precision Bioanalysis for Clinically Predictive PK/PD Evaluation
PhoenixBio Co., Ltd.
Source: PhoenixBio Co., Ltd. Official Website (https://phoenixbio.co.jp/)
Why Labcorp Holdings Inc.
PhoenixBio Co., Ltd.offers pharmacokinetic and hepatic metabolism studies using their proprietary PXB-mouse®, a humanized-liver chimeric mouse model. This platform enables the acquisition of data with high clinical correlation in ADME, drug–to-drug interaction studies, bridging the gap between preclinical and clinical stages.
With advanced LC-MS/MS-based bioanalysis, PhoenixBio Co., Ltd. provides aseamless workflow from plasma concentration measurement and metabolite identification to quantitative validation.
The company offersan integrated evaluation analysiscovering pharmacokinetics, hepatotoxicity, and safety with flexibility to accommodate complex modalities such as oligonucleotide and middle-molecule therapeutics.
For compounds where hepatic metabolism is a development bottleneck—or where quantitative, reproducible exposure data are critical—PhoenixBio Co., Ltd. delivers unmatched analytical precision and consistency.
【Efficacy and Pharmacology Studies】
Reproducing complex disease models—from exploratory discovery to clinically oriented efficacy evaluation
Reference: SMC Laboratories, Inc. official website (https://www.smccro-lab.com/jp/)
SMC Laboratories, Inc.
Recommended for
- Pharmaceutical and biotech companies pursuing novel drug discovery from the ground up
- Research teams aiming to identify promising candidates efficiently with limited resources
Why Choose SMC Laboratories, Inc.
for Efficacy and Pharmacology Studies
Comprehensive In-House Disease Models
SMC Laboratories, Inc. has established and operates a wide range of disease models in-house, covering oncology, inflammation, and metabolic disorders.
The company supports both exploratory evaluations in the preclinical stage and efficacy studies designed with clinical implementation in mind—offering broad coverage across therapeutic areas.
With expertise in optimizing study design according to disease progression and evaluation parameters, SMC Laboratories, Inc. provides flexible support across multiple phases of drug development.
Flexible Study Design and Strong Proposal Capabilities
Study designs can be customized based on clients’s target goals and development stages, including dose regimen, administration routes, and analytical endpoints.
Through close communication with research teams, SMC offers precise and practical designs tailored to each project’s targeted goal.
For both GLP/non GLP studies, the company prioritizes reproducibility and practicality—delivering reliable, high-quality efficacy evaluations.
Trusted by Start-ups, SMEs, and Academia
SMC’s flexible contract process accommodates small-scale or budget-limited studies without compromising quality.
From early-stage proof of concept studies to technical protocol reviewing consultations, their team provides expert guidance across diverse research needs.
For academic institutions and start-up companies who are facing financial or technical challenges, SMC Laboratories, Inc. serves as a dependable and resourceful development partner.
Examples of Disease Models Developed by SMC Laboratories, Inc.
SMC Laboratories, Inc. offers a diverse lineup of 25 proprietary disease mouse models, covering key research areas in inflammation, fibrosis, metabolic, and immuno oncology—including their patented STAM™ mouse model.Lineup of 25 disease model mice
The STAM™ model, widely recognized in MASH/NASH research, and the UUO model, a well-established renal fibrosis model, are two representative examples we will show below.
STAM™ Model (Progressive NASH–HCC Model)
The STAM™ mouse model replicates disease progression from fatty liver to MASH, fibrosis, and eventually hepatocellular carcinoma(HCC), along with its background of type 2 diabetes-like metabolic dysfunction.
This model closely mirrors human MASH/NASH–HCC pathology and is notable for its consistent development of liver cancer by 20 weeks of age.
It has been widely applied in cancer immunotherapy studies and cited in more than 70 peer-reviewed publications worldwide.
SMC Laboratories, Inc. official website
https://www.smccro-lab.com/jp/modellineup/stam-model/
UUO Model (Renal Fibrosis Screening Model)
The UUO (Unilateral Ureteral Obstruction) model induces renal fibrosis by obstructing one ureter, enabling rapid reproduction of major pathological changes associated with chronic kidney disease.
Within approximately two weeks, complex pathologies—such as interstitial fibrosis, tubular degeneration, and inflammatory cell infiltration—can be observed, making this an ideal model for early antifibrotic drug screening.
It is characterized by its short in-life phase and high reproducibility.
SMC Laboratories, Inc. official website
https://www.smccro-lab.com/jp/modellineup/uuo-induced-renal-fibrosis-model/
Pharmacology & Efficacy Case Studies – SMC Laboratories, Inc.
With over 1,000 global clients, SMC Laboratories, Inc. has an extensive track record in fibrosis, inflammation, metabolic disease, and immuno oncology studies.
Below are two examples of pharmacology studies that successfully advanced to Phase II clinical trials.
Efficacy evaluation in liver cirrhosis using the STAM™ model
Client: Galectin Therapeutics Inc. (NASDAQ: GALT)
Using the STAM™ model, Galectin Therapeutics ran an anti-fibrotic efficacy study for progressive MASH.
They were able to confirm significantly positive effect in fibrosis phase of the STAM model, which lead them to a Phase II clinical trial for MASH-related cirrhosis.
This case showcases the value of the STAM™ model as a translational bridge between preclinical to clinical research.
Reference: SMC Laboratories, Inc. official website (https://www.smccro-lab.com/jp/quality/)
Advancing NASH drug development at fibrotic stages
Client: Can-Fite BioPharma Ltd. (NYSE American: CANF / TASE: CFBI)
SMC provided MASH efficacy studies using the STAM™ model to evaluate drug response in liver fibrosis stages closely resembling clinical conditions.
The study supported the progression of Can-Fite’s drug candidate into an ongoing Phase II clinical trial—This also demonstrates the STAM™ model’s adaptability for assessing therapeutic efficacy across various disease stages.
Reference: SMC Laboratories, Inc. official website (https://www.smccro-lab.com/jp/quality/)
Company Information
| Company Name |
SMC Laboratories, Inc. |
| Location |
Technoport Kamata Center Bldg., 2-16-1 Minami Kamata, Ota-ku, Tokyo |
| Tel |
03-6715-9101 |
| Website |
https://www.smccro-lab.com/jp/ |
【Safety Studies】
Comprehensive Preclinical Safety Assessment for
First-in-Human (FIH) Applications
Reference: Labcorp Holdings Inc. official website (https://jp.labcorp.com/)
Labcorp Holdings Inc.
(Labcorp Drug Development)
Recommended for
- Global drug development companies aiming for FIH studies and eventual product commercialization
- Development teams seeking to efficiently outsource preclinical studies while ensuring compliance with international regulatory authorities
Why Choose Labcorp Holdings Inc.
for Safety Studies
GLP-Compliant Infrastructure and ICH-Compliant Data Reliability
Labcorp Holdings Inc. operates a fully GLP-compliant system capable of handling inspections by regulatory authorities including the FDA, EMA, and PMDA.
Non-clinical study designs are aligned with ICH M3(R2) guidelines, and meticulous management under global GLP standards ensures high-quality, reliable data.
Flexible reporting tailored to the submission strategies of different countries makes Labcorp Holdings Inc. a trusted partner for global drug development companies.
Comprehensive Long-Term Toxicity Studies Including Carcinogenicity and DART
Labcorp Holdings Inc. provides long term, expertise required studies such as two-year carcinogenicity studies and reproductive/developmental toxicity (DART) studies across SEG I–III.Even highly complex studies, which requires multiple species and generations are accomodated reliably through dedicated teams and optimized protocols.
Study designs can be flexibly adapted to ICH S1 and S5 guidelines.
Even highly complex studies, which requires multiple species and generations are accomodated reliably through dedicated teams and optimized protocols.
Study designs can be flexibly adapted to ICH S1 and S5 guidelines.
Integrated Toxicology and TK Support for FIH Applications
Labcorp Holdings Inc. provides a full non-clinical testing package for First-in-Human (FIH) submissions, integrating general toxicity, toxicokinetics (TK), and safety pharmacology studies.
Their support includes selecting of evaluation endpoints, scheduling, and integrated reporting, all tailored to the development stage and regulatory region.
This streamlined approach enables development teams to move effectively from preclinical to clinical phases, offering significant practical value.
Examples of Disease Models at Labcorp Holdings Inc.
Labcorp Holdings Inc. develops and utilizes specialized disease models to enable more precise risk assessment. These include rabbit models suited for reproductive and developmental toxicity (DART) studies and cardiac models used for cardiovascular safety evaluations.
Below is a selection of the disease models available at labcorp.
Rabbit model for DART study
(Reproductive and Developmental Toxicity Assessment Model)
In the DART test, which evaluates the risk of prenatal and postnatal developmental toxicity, labcorp established a reproductive developmental toxicity test using a rabbit model. Using rabbits, which are highly susceptible to the process of embryogenesis, Labcorp Holdings Inc. has achieved accurately detecting teratogenicity.
Comprehensive indicators including TOR (both fetal and maternal) observation are established through repeated administration during pregnancy, leading to accurate data collection in accordance with ICH-S5 under GLP standards.
Cardiovascular Safety Assessment Electrocardiographic Model (In Vivo Cardiovascular Dynamics Model)
Labcorp Holdings Inc. offers in vivo models for evaluating the cardiovascular effects of drugs. Using telemetry technology (PhysioTel™ L/M series) in rats and dogs, blood pressure, heart rate, and QT interval prolongation can be monitored in real time.
These models enable safety pharmacology assessments compliant with ICH S7A/S7B guidelines, supporting both early-stage screening and comprehensive preclinical analysis prior to clinical submission.
They provide high-precision data on cardiovascular drug effects, facilitating reliable decision-making in drug development.
Labcorp Holdings Inc. Safety Studies: Case Studies
Labcorp Holdings Inc. demonstrates high expertise in preclinical and early clinical pharmacokinetics (DMPK) studies as well as cardiotoxicity risk assessments.
In particular, ECG monitoring using telemetry technology to evaluate QT prolongation risk has been recognized as an effective tool for accelerating early-stage decision-making.
Here are examples of actual case studies conducted by Labcorp Holdings Inc..
Supporting Candidate Compound Evaluation via DMPK Studies
During early drug discovery, Labcorp Holdings Inc. provides integrated in vitro and in vivo DMPK studies to screen candidate compounds.
Parameters such as CYP inhibition, plasma protein binding, and permeability (PAMPA/Caco-2) are evaluated comprehensively, and results are linked to pharmacokinetic studies across multiple animal species.
Study designs that is focused on absorption and first-pass hepatic metabolism help determines strategies which may accelerate to clinical advancement.
Source: Labcorp Holdings Inc. Official Website – Metabolism Studies（https://jp.labcorp.com/biopharma/nonclinical/disciplines/metabolism）
Accomodating telemetry testing for risk assessment of QT prolongation
As part of ICH S7B-compliant safety pharmacology studies, Labcorp Holdings Inc. conducts telemetry experiments in canine models to monitor cardiovascular parameters in real time, including heart rate, blood pressure, and QTc variations.
These studies provide early screening of cardiovascular risks for candidate compounds.
Multiple dose groups, sensitive detection, and GLP-compliant reporting delivers robust data to determine the clinical progression and serve as safety documentation for FIH applications.
Source: Labcorp Holdings Inc.Official Website – Pharmacology Studies（https://jp.labcorp.com/biopharma/nonclinical/disciplines/pharmacology）
About Labcorp Holdings Inc.
| Company Name |
Labcorp Holdings Inc. |
| Location |
11F Harumi Triton Square Office Tower Y, 1-8-11 Harumi, Chuo-ku, Tokyo |
| Tel |
03-6837-9530 |
| Website |
https://jp.labcorp.com/ |
【Pharmacokinetic Studies】
High-Precision Bioanalysis for
Clinically-Oriented PK/PD Assessment
Source: PhoenixBio Co., Ltd. Official Website (https://phoenixbio.co.jp/)
PhoenixBio Co., Ltd.
Recommended for
- Researchers aiming to advance to clinical stage, requiring quantitative bioanalysis
- Professionals in Drug Development sector who is seeking highly translatable efficacy and safety data with a focus on hepatic metabolism
Why PhoenixBio Co., Ltd. is Ideal for Pharmacokinetic Studies
Clinically Relevant Models with Humanized Liver Function Model
PhoenixBio Co., Ltd.’s PXB® mice model maintains a high replacement rate of human hepatocytes, enabling metabolism profiles closely resembling humans.
This model is ideal for non-clinical studies emphasizing clinical translatability, including ADME evaluation, enzyme induction/inhibition assays, and drug-to–drug interaction predictions. They accommodates a wide range of compounds, from small molecules to biopharmaceuticals.
High-Precision Drug and Metabolite Measurement with LC-MS/MS
Using PXB® mice, plasma and tissue drug concentrations as well as metabolite profiling can be performed with high sensitivity via LC-MS/MS. Sample preparation and quantification validation can be tailored to study design, ensuring reliable GLP-compliant pharmacokinetic studies.
PhoenixBio Co., Ltd. excels at detecting low-concentration compounds and identifying complex metabolites.
Comprehensive Drug Evaluation with Safety and Efficacy in Mind
PXB® mice allow integrated assessment beyond pharmacokinetics, including liver toxicity and drug interaction studies. Key safety indicators such as liver injury markers and histological changes can be measured to provide consistent preclinical data.
Flexible study plans are also available for specialized modalities, including nucleic acid therapeutics and mid-sized molecules.
Examples of Disease Models Offered by PhoenixBio Co., Ltd.
PhoenixBio Co., Ltd. leverages its high expertise and proprietary technologies to provide disease models that combine high disease reproducibility with precise evaluation, generarting reliable preclinical data. Here are some examples of the disease models available at PhoenixBio Co., Ltd.:
MASH Disease Model – "MASH-c/PXB® Mouse"
A short-term MASH-like model created by feeding PXB® mice a CDAHFD (choline-deficient, amino acid–defined high-fat diet) for 12 weeks. This model reproduces human MASH-related pathology, including hepatocyte ballooning, Mallory-Denk–like bodies, elevated human ALT-1, and tissue inflammation.
Its relatively short timeline for bio marker expression makes it especially suitable for efficacy evaluation and pilot studies.
Cardiovascular Safety Assessment Electrocardiographic Model (In Vivo Cardiovascular Dynamics Model)
A long-term NASH model induced by feeding a GAN diet for 30 weeks. Based on PXB® mice retaining human hepatocytes, it faithfully reproduces progressive NASH features over time, including ballooning, Mallory-Denk bodies, inflammation, and elevated ALT.
This model is particularly suitable for chronic efficacy testing and applications in safety assessment.
PhoenixBio Co., Ltd. Pharmacokinetic Studies: Case Studies
PhoenixBio Co., Ltd. is highly regarded in the field of pharmacokinetics (DMPK), centered on the PXB® mouse, the world’s most widely used humanized liver chimeric mouse. Here, we introduce a few examples of pharmacokinetic studies conducted by PhoenixBio Co., Ltd..
Evaluating Human Clearance Prediction Using PXB® Mice
A validation study was conducted using three animal models—PXB® mice, monkeys, and rats—to quantitatively predict and compare human clearance for 30 compounds. By comparing absorption, distribution, metabolism, and excretion (ADME) behaviors across models, this study provided valuable insights for designing first-in-human dosing. This example confirmed the clinical relevance of PXB® mice, enhancing the accuracy of human extrapolation in early-stage pharmacokinetic evaluation.
Reference: PhoenixBio Co., Ltd. official website (https://phoenixbio.co.jp/services/dmpk-studies.html)
Predicting Human Metabolite Structures Using an Antiepileptic Drug
Using lamotrigine, an antiepileptic drug, PXB® mice and standard mice were compared to qualitatively predict human metabolite structures. By leveraging PXB® mice with human-like hepatic metabolism, researchers could obtain clinically relevant data, including differences in plasma concentration profiles, metabolite branching, and effects of polypharmacy. This study contributed to identifying human-specific metabolites, supporting translational pharmacokinetic evaluation.
Reference: PhoenixBio Co., Ltd. official website (https://phoenixbio.co.jp/services/dmpk-studies.html)
PhoenixBio Co., Ltd. Company Profile
| Company Name |
Phoenix Bio Inc. |
| Location |
3-4-1 Kagamiyama, Higashihiroshima City, Hiroshima Prefecture, Japan |
| Tel |
082-431-0016 |
| Website |
https://phoenixbio.co.jp/ |
List of CROs Published
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List of CROs and Agencies for Nonclinical Studies
Here, we introduce contract research organizations (CROs) and agencies that provide non-clinical study outsourcing and support services. Each company’s unique technologies, specialized models, and case studies are summarized in detail to help you select the most suitable partner for your nonclinical research needs.
SMC Laboratories, Inc.
Serving over 1,000 pharmaceutical and biotech companies across 30 countries, SMC Laboratories, Inc. offers extensive consulting and research support for efficacy evaluation studies. Their highly advanced patented technologies and well-equipped facilities enable high-quality nonclinical study outsourcing.
See Details of SMC Laboratories, Inc.’ Nonclinical Study Services
Drug Safety Testing Center Co., Ltd.
A leading domestic CRO specializing in hERG assays, with extensive experience and proven results. Since 2001, they have provided services in compliance with safety pharmacology guidelines and have been entrusted by numerous companies.
See Details of Drug Safety Testing Center Co., Ltd.’s Nonclinical Study Services
New Drug Research Center
Experienced in evaluating a wide range of pharmaceutical efficacy, providing highly reliable data through pharmacokinetic measurements by skilled analysts. They also conduct special staining and sample preparation for optical and electron microscopy.
See Details of NewNew Drug Research Center’s Nonclinical Study Services
Anpyo Center
Provides various efficacy pharmacology tests covering cardiovascular, allergy, anti-fatigue effects, and pharmacodynamic equivalence tests for generic drugs. Strong track record in pathological diagnostics, supporting studies from small to large animals.
See Details of Anpyo Center’s Nonclinical Study Services
Mediford Corporation
Offers medical writing services and studies using a variety of disease models for pharmacology testing. Their expertise covers both new and established disease models, supporting a wide range of disease indication.
See Details of Mediford Corporation’s Nonclinical Study Services
BoZo Research Center Inc.
Supports drug discovery projects from strategy consultation to individual study execution, focusing on lead compound optimization. Offers high-quality and reliable efficacy pharmacology studies to numerous companies.
See Details of BoZo Research Center Inc.’s Nonclinical Study Services
CMIC HOLDINGS Co., Ltd.
With extensive experience in nonclinical studies, CMIC HOLDINGS Co., Ltd. supports drug development planning and regulatory documentation. Their 30+ years of CRO experience allows them to propose services tailored to each client’s needs.
See Details of CMIC HOLDINGS Co., Ltd.’ Nonclinical Study Services
SNBL INA Ltd.
Specialized in safety and efficacy evaluation across pharmaceuticals, foods, chemicals, and medical devices, with unique expertise in central nervous system and ophthalmology pharmacology tests.
See Details of SNBL INA Ltd.’s Nonclinical Study Services
SHIN NIPPON BIOMEDICAL LABORATORIES, LTD. (SNBL)
Provides comprehensive services across all stages of drug development. With over 60 years of experience, they deliver high-quality nonclinical testing services backed by proven technical expertise.
See Details of SHIN NIPPON BIOMEDICAL LABORATORIES, LTD.’ Nonclinical Study Services
Nihon Medi-Physics Co.,Ltd.
Handles pharmaceuticals, radiopharmaceuticals, as well as regenerative medicine products. All manufactured radiopharmaceuticals undergo a wide range of quality testing, and only the ones that meet the strict standards defined in their quality control criteria are provided.
See Details of Nihon Medi-Physics Co.,Ltd.’ Nonclinical Study Services
Nissei Bilis Co.,Ltd.
Specializes in efficacy pharmacology studies across multiple disease areas. Offers toxicity testing using severely immunodeficient animals and efficacy studies leveraging established evaluation systems.
See Details of Nissei Bilis Co.,Ltd.’ Nonclinical Study Services
TRANS GENIC INC.
See Details of Transgenic’s Nonclinical Study Services
TRANS GENIC INC.
Non-clinical Contract Testing Services
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PhoenixBio Co., Ltd.
Specializes in nonclinical studies using PXB® mice (over 70% of the liver replaced with human hepatocytes). Produces 100 PXB® mice weekly, selecting the appropriate animals for studies.
See Details of PhoenixBio Co., Ltd.’s Nonclinical Study Services
Nihon Bioresearch Inc.
Conducting studies using minipigs at its Hashima Research Facility since 1995. The company also supports nonclinical studies for medical devices and regenerative medicine, as well as infectious disease related testing.
See Details of Nihon Bioresearch Inc.r’s Nonclinical Study Services
Safety Research Institute for Chemical Compounds Co., Ltd.
The institute has over 50 years of experience in nonclinical studies. As a GLP-compliant facility for pharmaceuticals and pesticides, it conducts reproductive and developmental toxicity tests in accordance with various guidelines.
See Details of Compound Safety Research Institute for Chemical Compounds Co., Ltd.’s Nonclinical Study Services
Nemoto Science Co.,Ltd.
Specializes in PK studies and synthesis outsourcing, including tritium-labeled compounds, supporting studies from drug discovery to development.
See Details of Nemoto Science’s Nonclinical Study Services
WAKENYAKU CO.,LTD.
Founded in 1972, the company has operated through both dealer and manufacturer divisions. It aims to provide fast and precise support for research and development fields, including the biotech sector.
See Details of WAKENYAKU CO.,LTD.’s Nonclinical Study Services
YAKUKENSHA CO.,LTD.
Supports a wide range of testing including blood and urine analysis, toxicity testing, and safety pharmacology. Offers full support from CRISPR/Cas9 genome-edited mouse production to phenotyping and breeding.
See Details of YAKUKENSHA CO.,LTD.’s Nonclinical Study Services
EP Mediate Co.,Ltd.
Specializes in nonclinical (in vivo and in vitro) functional and safety evaluations, as well as identification of active components and development of qualitative and quantitative analysis. Since 2012, the company have partnered with a dedicated nonclinical testing facility to conduct more advanced and complexed studies.
See Details of EP Mediate Co.,Ltd.
’s Nonclinical Study Services
Sekisui Medical Co.,Ltd.
Provides custom synthesis of radioisotope-labeled compounds and PK studies, offering cutting-edge nonclinical studies based on GMP experience.
See Details of Sekisui Medical Co.,Ltd.’s Nonclinical Study Services
Shikoku Rika
Founded in 1979, promotes life sciences research in Shikoku region in Japan and offers licensed nonclinical studies using genetically modified mice.
See Details of Shikoku Rika’s Nonclinical Study Services
Iwase Cosfa Co.,Ltd.
Partnered with BIOTOXTECH (Korea), serves as Japan’s exclusive agency for clinical safety testing. Supports studies in cosmetics, food, chemicals, pesticides, and pharmaceuticals.
See Details of IIwase Cosfa Co.,Ltd.’s Nonclinical Study Services
SRL,Inc.
The company receives testing requests daily from hospitals and clinics nationwide. It collaborates with partnered companies to support developing new biomarkers, which is essential for pharmaceutical drug development, assisting clients all the way through regulatory submission.
See Details of SRL,Inc.’s Nonclinical Study Services
Sumika Chemical Analysis Service, Ltd.
Independent since 1972, Sumika Analytical Center provides concentration measurements under various regulatory frameworks for nonclinical and clinical studies across industries.
See Details of Sumika Chemical Analysis Service, Ltd.’s Nonclinical Study Services
Clino Corporation
Supports minipig nonclinical studies in collaboration with animal suppliers, including study coordination and animal management before, during, and after testing.
See Details of Clino Corporation’s Nonclinical Study Services
Shokukanken Inc.
One of Japan’s few CROs for veterinary pharmaceuticals, conducting studies spanning from “farm to table” and providing innovative proposals.
See Details of Shokukanken Inc.’s Nonclinical Study Services
LibraMedicina, Inc.
As a trusted CRO, the company has successfully supported numerous IND applications in the U.S. and Taiwan, obtaining approval from the FDA. Based on its track record, it provides clients with well-designed experiment planning tailored to each study.
See Details of LibraMedicina, Inc.’s Nonclinical Study Services
Food and Drug Safety Center
Provides safety testing for pharmaceuticals, medical devices, and health foods, following MHLW guidelines, ISO10993, FDA, ASTM, and OECD standards.
See Details of Food and Drug Safety Center’s Nonclinical Study Services
Hamamatsu Pharma Research
Specializes in nonclinical studies using non-human primates (NHPs), supporting pharmacology and PK studies for new drug candidates.Specializing in non-clinical studies with non-human primates (NHPs)supporting pharmacology and PK studies for new drug candidates.
See Details of Hamamatsu Pharma Research’s Nonclinical Study Services
Takara Bio Inc.
Provides GLP safety testing based on Mediford Corporation’s expertise in nonclinical studies, supporting gene therapy and cell therapy research from development to clinical application.
See Details of Takara Bio Inc.’s Nonclinical Study Services
FUJIFILM Wako Pure Chemical Corporation
Leverages long-standing expertise in food analysis to support various analytical and drug discovery services, including in vivo nonclinical safety, efficacy, and pharmacology studies.
See Details of FUJIFILM Wako Pure Chemical Corporation’s Nonclinical Study Services
Inotiv, Inc.
A CRO providing integrated support from drug discovery to clinical trial applications, offering diverse research models including renal, metabolic, immunodeficient, and inflammation models.
See Details of Inotiv, Inc.’s Nonclinical Study Services
Cellomatics BioSciences Ltd.
Founded in 2015 in Nottingham, UK, providing services focused on oncology, immuno-oncology, immunology, inflammation, and respiratory diseases, with highly customizable in vitro bio-assays.
See Details of Cellomatics Biosciences Ltd.’ Nonclinical Study Services
Certis Oncology Solutions, Inc.
is a life sciences company aiming for precision medicine in cancer therapy, featuring the proprietary platform Certis Oncology Intelligence®.
See Details of Certis Oncology Solutions, Inc.’ Nonclinical Study Services
Champions Oncology, Inc.
Provides nonclinical studies from early drug discovery to immuno-oncology using proprietary models. Maintains over 1,400 patient-derived cancer models.
See Details of Champions Oncology,Inc.’s Nonclinical Study Services
ChemPartner PharmaTech Co., Ltd.
With headquarters in China and a US office in San Francisco, offers services from early drug discovery to nonclinical development, including IND submission packages based on proven track records.
See Details of ChemPartner PharmaTech Co., Ltd.s Nonclinical Study Services
Immusmol SAS
Immusmol SAS is a preclinical and translational research CRO specializing in the field of cancer immunotherapy.Consistent support for analysis using invitro tests, animal models, and human samples.
We support research and development from multiple perspectives, including evaluation of immune checkpoint inhibitors and biomarker discovery.
Immusmol SAS's
Non-clinical Contract Testing Services
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FibroFind
We undertake non-clinical studies using our proprietary human tissue slice (PCTS) technology, ranging from drug efficacy evaluation to elucidation of mechanism of action.Highly accurate fibrosis pathology models in liver, kidney, and lung that reproduce the human biological environmentThe company's major strength is that it is able to provide a wide range of services to its customers.
FibroFind's
Non-clinical Contract Testing Services
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Gubra A/S
Specializing in the fields of metabolism and fibrosis, we undertake advanced non-clinical studies from initial exploration to MoA elucidation.Possesses MASH models that reproduce human pathological conditions and analysis know-how using AI and 3D technologiesGubra A/S's major strength is that it is a company that has been in the business for many years.
Gubra A/S's
Non-clinical Contract Testing Services
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Hera BioLabs
We are a U.S. CRO utilizing our proprietary immunodeficient rat, the SRG Rat, and advanced gene editing technology. by a rat model with metabolic functions more similar to humans than mice,Provides highly predictive clinical data and rich biological samples in cancer researchI will do so.
Hera BioLabs
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Hooke Laboratories, LLC
Based in Massachusetts, USA,Pre-clinical CRO specializing in inflammation and autoimmune diseasesIt is. High reproducibility is achieved through EAE and CIA models using high-quality kits developed in-house. We strongly support validation of drug targets and evaluation of drug efficacy with our expert knowledge and technology.
Hooke Laboratories, LLC
Non-clinical Contract Testing Services
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Imavita S.A.S.
Based in France,Providing high quality contract testing services combining proprietary imaging technology and disease models.The system is particularly strong in the areas of dermatology and bone disease. It is particularly strong in the areas of dermatology and bone disease, and its non-invasive measurement over time enables reliable quantitative data to be obtained while reducing the number of animals used.
Imavita's S.A.S.
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Jubilant Biosys Limited
The company has offices in India and Europe,Global CRDMO providing integrated support from early drug discovery to manufacturingIt is. We provide high-quality data in a wide range of disease areas, including oncology, metabolic diseases, and pain. Our advanced expertise and well-developed infrastructure help streamline the drug discovery process with speed and accuracy.
Jubilant Biosys Limited'
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Labcorp (formerly Labcorp Drug Development)
Headquartered in the U.S., with an extensive networkGlobal full-service contract research organization (CRO)Based on more than 40 years of experience, we support a wide variety of modalities, from small molecules to CAR-T and gene therapy. We strongly support the reduction of development risks and the acceleration of clinical development through our advanced disease models and scientific knowledge.
Labcorp (formerly Labcorp Drug Development)
Non-clinical Contract Testing Services
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Lovelace Biomedical
Based in New Mexico, USA,Non-profit, non-clinical CRO with strengths in respiratory diseases, infectious diseases, and gene therapyWith a long history dating back to 1947 and a large scale GLP-compliant facility, the company supports successful drug development by building complex disease models and evaluating toxicities in a highly biosafety environment.
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MD Biosciences
Based in the U.S. and Israel,Pre-clinical CRO specializing in neurological diseases, pain, and inflammationWith over 30 years of experience and strength in translational models using pigs, we provide multifaceted evaluations that combine electrophysiology and tissue analysis. We support drug discovery and development quickly and flexibly with highly reliable data with an eye toward clinical trials.
MD Biosciences.
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MELIOR DISCOVERY, INC.
Based in Pennsylvania, USA,Non-clinical CRO with in-house developed screening platformIt is a We are a non-clinical CRO with a screening platform developed in-house. We provide rapid screening for drug repositioning and indication expansion using "theraTRACE," and provide over 150 different disease models and speedy data to strongly back up early decision making.
MELIOR DISCOVERY, INC.'s
Non-clinical Contract Testing Services
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