UNITECH Co.,Ltd.

UNITECH Co.,Ltd. has evolved from genetic research to drug discovery support and conducts nonclinical studies under non-GLP conditions—covering pharmacology (PD), toxicology, and pharmacokinetics—through in-house contract services. With a high level of expertise and a rapid testing framework, UNITECH Co.,Ltd. provides strong support from the early stages of new drug development.

Features of UNITECH Co.,Ltd.’s Non-Clinical Contract Testing Services

Contract-based testing from disease-model creation

UNITECH Co., Ltd. has extensive experience establishing a variety of mouse disease models and conducts pharmacology, toxicology, and pharmacokinetic studies in an integrated manner. With diverse models addressing inflammatory and immune diseases, metabolic diseases, cancer, and cardiovascular diseases, the team can design rigorous studies aligned with specific research objectives.

By handling the entire workflow in-house—from model generation to study execution and data analysis—UNITECH Co., Ltd. maintains stable quality while enabling flexibility.

Support for multifaceted pharmacology, toxicology, and pharmacokinetics

UNITECH Co.,Ltd. conducts pharmacology, toxicology, and pharmacokinetic studies in both in vitro and in vivo systems. In addition to efficacy evaluations using genetically engineered mice and other disease models, the organization performs non-GLP safety assessments such as acute toxicity and repeated-dose toxicity studies, as well as pharmacokinetic evaluations using LC–MS/MS.

Testing coverage spans from the discovery stage of drug candidates through preclinical development.

Flexible support from the study-design stage

A contracting model from the earliest stages allows UNITECH Co.,Ltd. to propose study designs and analytical methods tailored to each request, including disease-model selection and adjustment of analysis items.

A stepwise approach can be provided according to study scale—from initial evaluations in a small number of animals to full confirmation of drug efficacy—optimizing study content as research and development progress or policies change.

Examples of Disease Models Available at UNITECH Co.,Ltd.

Extensive experience with genetically engineered mouse models

Backed by a track record of producing more than 1,300 lines of genetically engineered mice, the company can develop a wide range of disease models. Specifically, models can be constructed to meet varied research needs, including cancer models, Alzheimer’s disease models, organ-specific transgenic (Tg) mice (e.g., cardiac muscle, kidney), conditional KO/KI mice, null KO, BAC-Tg, and point-mutation models.

Even when production is challenging, UNITECH Co.,Ltd. provides integrated in-house support from vector construction through ES cell production and analysis. A complete support framework—from design to delivery—is in place, and the company’s policy is to “not abandon a project unless cell production is impossible.”

Reference: UNITECH Co.,Ltd.'s official website (https://www.uniqtech.co.jp/drug-discovery/)

UNITECH Co.,Ltd. Non-Clinical Case Studies

Anti-tumor evaluation model using human colon cancer cells

A case study in which human colon cancer cells (HT-29) were subcutaneously transplanted into nude mice to evaluate anti-tumor efficacy. Tumor growth was measured periodically to confirm the efficacy of the test article under non-GLP conditions.

By utilizing a cancer xenograft model, screening can be performed in an evaluation environment closer to clinical conditions. This model is effective for selecting candidate compounds in the early stages of drug discovery because it can also be used to evaluate tumor shrinkage and toxicity.

Reference: UNITECH Co.,Ltd.'s official website (https://www.uniqtech.co.jp/mouse-production-results/)

UNITECH Co.,Ltd. Information