Japan SLC,Inc.

Japan SLC conducts non-clinical studies in-house, including GLP-compliant safety studies and pharmacological efficacy evaluations using a wide range of disease models, in addition to supplying laboratory animals.

As a fully integrated contract research organization, the company provides comprehensive support from animal breeding to antibody production.

Features of Japan SLC,Inc.’s Contract Services for Non-Clinical Studies

GLP-Compliant Safety Studies

Japan SLC,Inc. conducts in-vitro and in-vivo safety studies in compliance with the GLP standard for pharmaceutical drugs and medical devices.
Testing includes cytotoxicity, acute toxicity, and pyrogenicity evaluations, as well as studies aligned with GMP and QMS standards for target products.

With a flexible testing framework, the company can accommodate both GLP and non-GLP studies, supporting research from the early development phase through commercialization.

Flexible Study Design with Extensive Disease Models in Animal

Japan SLC,Inc. possesses a diverse portfolio of disease models in animals —including diabetes (STZ-induced), hyperlipidemia, arthritis, and pulmonary fibrosis—enabling tailored study designs depending on clients’needs.
In addition to models that are induced by diet, surgical, and chemical, the company also conducts specialized studies using ferrets and rabbits.

Japan SLC,Inc. not only performs contract studies but also supplies these disease model animals for external research uses.

Comprehensive Capability in Animal Supply and Antibody Production

The company offers end-to-end services covering the entire research process—from supplying and breeding laboratory animals to conducting pharmacological, safety, and pharmacokinetic studies, and antibody production.
Both polyclonal and monoclonal antibodies can be produced, with additional services such as splenocyte or PBMC collection available.

This integrated system enables Japan SLC,Inc. to deliver animals, technologies, and testing systems in one streamlined package, customized to the clients’ research goals and timelines.

An Example of Disease Model Provided by Japan SLC,Inc.

OSK-KI: A Genetically Engineered Mouse Model for Alzheimer’s Disease Research

The OSK-KI (C57BL/6-Tg(OSK-KI)) is a genetically modified mouse designed to overproduce amyloid-β, serving as a highly reproducible model for Alzheimer’s disease research.

A patent application has been filed for the model, which is recognized for its clinical translatability. The use of the model requires a research license agreement depending on the intended application.

Japan SLC,Inc. provides a wide range of advanced genetically engineered animal models to support drug discovery and disease mechanism studies.

Reference: Japan SLC,Inc. official website (http://www.jslc.co.jp/animals/mouse.php)

Example of Non-Clinical Study Conducted by Japan SLC

Pharmacological, Pharmacokinetic, and Immunological Studies Using Various Disease Models

Japan SLC,Inc. conducts a wide array of non-clinical studies utilizing animal models such as STZ-induced diabetes, drug-induced arthritis, and pulmonary fibrosis diseases.

Both GLP and non-GLP studies are available, including immunogenicity (antibody production) assessments.

Study designs can be flexibly tailored to the research purpose and development stage.

Reference: Japan SLC,Inc. official website http://www.jslc.co.jp/service/tests.php

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