Crown Bioscience, Inc.

Crown Bioscience, Inc. is a contract research organization (CRO) specializing in non-clinical studies, with proprietary disease models and in-house research facilities. The company supports drug discovery across multiple therapeutic areas, including immuno oncology and metabolic diseases, providing comprehensive research solutions. Crown Bioscience, Inc. operates globally, with facilities across Asia, Europe, and the United States

Features of Crown Bioscience, Inc.’s Non-Clinical Study Services

Advanced Immunosafety Assessment Using Humanized Mouse Models

Crown Bioscience, Inc. utilizes humanized mouse models, such as HuGEMM™ and HuCELL™, in which human targets are knock-in, to conduct in vivo evaluation of complex on-target and off-target toxicities (irAEs) induced by immunotherapeutics including immune checkpoint inhibitors, bispecific antibodies, and ADCs. Efficacy and toxicity can be measured simultaneously within the same animal species, allowing accurate determination of the therapeutic index and ensuring rapid, reliable data delivery.

Precise Physiological Function Evaluation Using Continuous Monitoring Technology

In safety pharmacology studies using rodents, continuous and long-term monitoring of blood pressure, heart rate, and blood glucose is conducted through radiotelemetry and DSI telemetry systems.

This enables accurate capture of fluctuations in cardiovascular, metabolic, and renal functions, providing a comprehensive understanding of compound-related adverse effects.

Long-term follow-up studies such as four week study is also available, enhancing the reliability of the overall safety profile.

Integrated Pharmacokinetic Analysis Through DMPK Services Across Multiple Species and Dosing Routes

At Crown Bioscience, in vivo pharmacokinetic (PK) evaluation is also available for both small- and large-molecule drugs. They support multiple administration routes including intravenous, oral, intraperitoneal, subcutaneous, and intramuscular dosing.

Studies can be performed in a variety of species—mouse, rat, rabbit, dog, NHP, pig, and human. PK profiles include single, repeated, and cassette dosing, as well as MTD studies and tissue distribution/excretion analysis.

They deliver high-quality data consistently under robust quality assurance framework.

Example of Disease Models Provided by Crown Bioscience, Inc.

Cancer Models that Can Reproduce Human Immune System Using the MiXeno™ Platform

The MiXeno™ platform is a unique in vivo model that combines PBMC (human peripheral blood mononuclear cells) with cell line-derived xenograft (CDX) models, enabling partial reconstitution of the human immune system.

This allows evaluation of immune responses within the human tumor microenvironment. By reconstructing limited T-cell populations, this model allows rapid and cost-effective assessment of drug efficacy for multiple cancer types, including breast, colorectal, lung, lymphoma, and melanoma.

Reference URL:.
https://crownbio.jp/model-systems/in-vivo/mixeno

Case Study

Orthotopic Models Using High-Frequency Ultrasound Imaging

Crown Bioscience, Inc. has established orthotopic (in situ transplantation) tumor models using high-frequency (HF) ultrasound technology, enabling accurate tumor implantation and real-time tracking in organs such as the liver and pancreas. Combined with non-invasive, high-resolution 2D and 3D imaging, this approach reduces animal burden, increases throughput, and allows rapid and reproducible tumor growth evaluation.

Reference:
https://www.crownbio.com/model-systems/in-vivo/orthotopic-models-with-ultrasound-imaging

Company Information