LSI Medience Corporation

LSI Medience Corporation is a contract research organization providing GLP-compliant non-clinical studies. These studies are conducted at the LSIM Safety Science Institute, a consolidated subsidiary. Through testing performed within its own group facilities, the company supports the delivery of high-quality data that meets international regulatory standards.

Features of LSI Medience Corporation’s Non-clinical Contract Services

Highly reliable GLP-compliant testing framework

LSIM Safety Science Institute—the subsidiary responsible for non-clinical studies—has obtained multiple GLP certifications, including Pharmaceuticals GLP. The institute is highly regarded by third-party authorities such as Japan’s Ministry of Health, Labour and Welfare, the Ministry of Agriculture, Forestry and Fisheries, the Ministry of the Environment, as well as being recognized as compliant with OECD principles.

Within its in-house facilities, LSI Medience Corporation has established a system capable of conducting world-class safety studies for pharmaceuticals, agrochemicals, and chemical substances.

Comprehensive non-clinical capabilities including toxicology and pharmacokinetics

LSIM Safety Science Institute conducts a broad spectrum of non-clinical studies— toxicity testing (acute, repeated-dose, reproductive and developmental, and genotoxicity) , pharmacokinetics, metabolite identification, and analytical method validation.

A wide range of animal species can be used, including rats, mice, dogs, monkeys, and rabbits. Study designs can be customized to meet various regulatory and submission requirements. The institute supports development not only for pharmaceuticals but also agrochemicals and chemical substances across different development stages.

Strong compliance with global regulations and robust quality documentation

Because LSIM Safety Science Institute adheres to OECD guidelines in addition to Japanese GLP, it is capable of conducting studies intended for international joint development programs and overseas regulatory submissions.

The institute maintains an internal Quality Assurance department that ensures rigorous quality control, including audits and reporting. Study protocols and final reports can also be prepared in English, providing strong support for documentation required by international regulatory agencies.

Examples of Disease Models Available at LSI Medience Corporation

Pathological models for pain and inflammation assessment

As part of their pharmacology testing services, LSIM Safety Science Institute conducts non-clinical studies using various pathological models designed for the evaluation of pain and inflammation.

In their animal models, they analyse the efficacy of anti-inflammatory agents, analgesics, and other candidate compounds. Pharmacological effects—including mechanism of action, dose-response curve, and duration of the effect—are evaluated to support a smooth transition to the next clinical development stages.

Details regarding specific model protocols can be discussed during preliminary consultations.

Reference: LSI Medience Corporation Official Website https://www.ankaken.dmsv.tokyo/test/pharmacology.html

LSI Medience Corporation Non-clinical Case Studies

DMPK characterization support for drug candidate compounds

The official website does not currently provide publicly available case study information.

LSI Medience Corporation Company Information