THE JACKSON LABORATORY JAPAN, INC.

THE JACKSON LABORATORY JAPAN, INC. is the Japanese subsidiary of The Jackson Laboratory (U.S.), a global leader in mouse model development and biomedical research. The company provides comprehensive mouse model resources and research support services.
In the field of non-clinical testing, it conducts studies in-house as well as contract research and consulting in collaboration with its U.S. headquarters.

Features of THE JACKSON LABORATORY JAPAN, INC.’s Non-Clinical Study Services

Pharmacology Studies Using Disease Model Mice

THE JACKSON LABORATORY JAPAN, INC. conducts pharmacological efficacy studies in a broad range of disease areas, including oncology, diabetes, inflammation, and pain.

Analyses can be performed using high-quality JAX® Mice and PDX models developed by The Jackson Laboratory in the U.S. The company has established a specialized testing platform that is unique to an experimental animal research institute, ensuring genetic stability and model reliability.
With these capabilities, THE JACKSON LABORATORY JAPAN, INC.contributes to the evaluation of efficacy for novel drug candidates.

Expertise in Pharmacokinetic Evaluation of Antibody Drugs

The company also specializes in pharmacokinetic (PK) studies for antibody-based drugs. Using FcRn humanized mouse models, THE JACKSON LABORATORY JAPAN, INC. conducts detailed analyses such as half-life comparisons to evaluate pharmacokinetics and bioavailability.

Its testing infrastructure supports a wide range of research needs—from early to late stages—by offering method development, parameter quantification, and study optimization. The use of genetically engineered animal models enables similar evaluation methodsto clinical conditions.

Animal Health Management with Proprietary Environmental Monitoring Technology

THE JACKSON LABORATORY JAPAN, INC. has implemented a unique environmental monitoring system that captures and analyzes airborne particulates from the exhaust plenums of individually ventilated cage racks.

This technology enables highly sensitive detection of microbial contamination and maintains a high level of facility cleanliness.
By ensuring the stable health of laboratory animals, the company enhances the reproducibility and reliability of non-clinical studies.
Such controlled facility environments also help minimize the risk of pathogen intrusion—an essential foundation for high-precision experimental outcomes.

Example of Disease Models Provided by THE JACKSON LABORATORY JAPAN, INC.

PDX Models and Humanized Mice Developed by The Jackson Laboratory

NSG mice (NOD scid gamma) in the PDX model are severely immunodeficient, lacking T, B, and NK cells, and demonstrate a remarkably high engraftment rate for human tumor tissues.
Due to the lack of rejection responses, human tumor characteristics can be preserved during proliferation.
By introducing human immune cells, these models can also serve as humanized mice that are suitable for evaluating tumor–immune interactions in preclinical research.

Reference: THE JACKSON LABORATORY JAPAN, INC. official website https://www.jax.or.jp/product-and-service/import/jax-pdx-hu

Non-Clinical Case Study by THE JACKSON LABORATORY JAPAN, INC.

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