KAC Co., Ltd.

KAC is a contract research organization (CRO), that supports development of pharmaceutical/regenerative medical products. The company provides an end-to-end system, which covers the entire Non-clinical study process— supplying laboratory animals, conducting animal studies, performing evaluations, and analyzing results— entirely in-house.

Features of KAC Co., Ltd.’s Non-Clinical Study Services

Safety evaluation system for single and repeated dose toxicity studies

KAC offers a range of toxicity studies with a focus on single-dose and repeated-dose toxicity tests. The company also conducts local irritation studies (rabbit), sensitization testing, and other evaluations required for the non-clinical assessment of pharmaceuticals/regenerative medical products.

Flexible study designs with multiple animal species such as mice and rats are available. This enables a tailored proposal to each client's study needs.

Biological safety testing in accordance with ISO 10993

KAC conducts biological safety studies compliant with ISO 10993, including cytotoxicity and sensitization tests, supporting non-clinical evaluations for medical devices and regenerative medical products.

The company provides reliable safety data generated under test systems which are aligned with international standards. Examples include a variety of irritation assays and material reactivity assessments. Evaluation items can be customized according to the characteristics of client’s compound.

GLP-compliant testing system ensuring data reliability

KAC is a GLP(Good Laboratory Practice) compliant facility. They provide all of our non-clinical studies according to the GLP standard. The organization maintains appropriately managed facilities and operations to ensure the reliability and traceability of study data.

KAC is recognized as a research institution who continues their work to improve quality of each study.

Disease Models at KAC Co., Ltd.

CCI model (rat)

KAC supports studies using the rat Chronic Constriction Injury (CCI) model, one of the most widely used models for neuropathic pain. By applying mild constriction to peripheral nerves, changes in pain-related behaviors can be evaluated.

This model is commonly used for pharmacological efficacy studies, such as measuring responses to mechanical stimuli via the von Frey test. It enables the assessment of candidate therapeutics for neuropathic pain.

Reference:
https://www.kacnet.co.jp/service/bioscience/pain-test/pain-test.html

KAC Co., Ltd. Non-Clinical Study Case Examples

No case studies were available on the official website.

Company Information