A site where you can find recommended contractors for non-clinical testing｜effical " Non-Clinical CROs and Agencies " KAC Co., Ltd.

KAC Co., Ltd.

Table of Contents

KAC is a contract research organization (CRO), that supports development of pharmaceutical/regenerative medical products. The company provides an end-to-end system, which covers the entire Non-clinical study process— supplying laboratory animals, conducting animal studies, performing evaluations, and analyzing results— entirely in-house.

Features of KAC Co., Ltd.’s Non-Clinical Study Services

Safety evaluation system for single and repeated dose toxicity studies

KAC offers a range of toxicity studies with a focus on single-dose and repeated-dose toxicity tests. The company also conducts local irritation studies (rabbit), sensitization testing, and other evaluations required for the non-clinical assessment of pharmaceuticals/regenerative medical products.

Flexible study designs with multiple animal species such as mice and rats are available. This enables a tailored proposal to each client's study needs.

Biological safety testing in accordance with ISO 10993

KAC conducts biological safety studies compliant with ISO 10993, including cytotoxicity and sensitization tests, supporting non-clinical evaluations for medical devices and regenerative medical products.

The company provides reliable safety data generated under test systems which are aligned with international standards. Examples include a variety of irritation assays and material reactivity assessments. Evaluation items can be customized according to the characteristics of client’s compound.

GLP-compliant testing system ensuring data reliability

KAC is a GLP(Good Laboratory Practice) compliant facility. They provide all of our non-clinical studies according to the GLP standard. The organization maintains appropriately managed facilities and operations to ensure the reliability and traceability of study data.

KAC is recognized as a research institution who continues their work to improve quality of each study.

3 Specialized Pre-clinical CROs for Advanced Drug Discovery

Disease Models at KAC Co., Ltd.

CCI model (rat)

KAC supports studies using the rat Chronic Constriction Injury (CCI) model, one of the most widely used models for neuropathic pain. By applying mild constriction to peripheral nerves, changes in pain-related behaviors can be evaluated.

This model is commonly used for pharmacological efficacy studies, such as measuring responses to mechanical stimuli via the von Frey test. It enables the assessment of candidate therapeutics for neuropathic pain.

Reference:
https://www.kacnet.co.jp/service/bioscience/pain-test/pain-test.html

KAC Co., Ltd. Non-Clinical Study Case Examples

No case studies were available on the official website.

Company Information

Address	40 Nishi Gekko-cho, Nishinokyo, Nakagyo-ku, Kyoto, Japan
Tel	075-801-9311
Website	https://www.kacnet.co.jp/

3 Recommended Contract Research Organizations for Non-Clinical Studies
— by Target goal and Expertise

In drug discovery, the quality and efficiency of non-clinical studies have a direct impact on clinical success rates, development costs, and overall length of time required in R&D. In recent years, there has been more demand for clinically relevant data, globally accepted reliability, and accurate early-stage screening. Thus, it is more important than ever to select the right CRO (Contract Research Organization) for strategic approach.
In this article, we highlight three CROs with proven technical capabilities, expertise, and long standing track records. These are our TOP 3 choices based on their capabilities and the specific target goals of the researchers for their non-clinical studies.

Pharmacology (Efficacy) Studies
Replicate unknown pathological models and
Discovery to clinically oriented drug evaluation

SMC Laboratories, Inc.

Reference: SMC Laboratories, Inc. official website (https://www.smccro-lab.com/jp/)

SMC Laboratories, Inc. has established a disease models using patented mouse technologies. The company has established proprietary pathological models—particularly in liver disease and fibrosis—and continues to expand their approach across a wide range of models in cancer, inflammation, and metabolic diseases.
From exploratory research to clinically oriented efficacy evaluation, SMC offers customized study designs, dosing strategies, and evaluation analysis tailored to each project. Their collaborative approachallows researchers to discuss and refine study plans together with SMC’s expert scientists.
With flexible small-scale study options and strong technical support, SMC Laboratories, Inc. is an ideal partner for start-ups, biotech ventures, and academic institutions alike.

Consult study design and disease model development
with SMC Laboratories, Inc.

Consult SMC Laboratories
Call us

Safety Studies
Comprehensive Safety Evaluation for FIH Applications

Labcorp Holdings Inc.
(Labcorp Drug Development)

Reference: Labcorp Holdings Inc. official website (https://jp.labcorp.com/)

Labcorp Holdings Inc. provides a fully integrated GLP testing system aligned with international regulatory standards, including FDA, EMA, and PMDA requirements. All studies are conducted under ICH-compliant quality assurance, making it ready for data submission.
The company has extensive expertise in long-term toxicity studies such as Segment I–III reproductive and carcinogenicity studies, as well as 2-year chronic toxicity assessments.
Labcorp Holdings Inc.’s comprehensive approach enables sponsors to efficiently outsource the entire preclinical package from toxicology, toxicokinetic (TK), and safety pharmacology study design to execution. This accelerates a path to First-in-Human (FIH) trials. For most of the global drug developers, this all-in-one service structure minimizes cost, risk, and expedite the time before advancing to clinical phase.

Consult Labcorp Holdings Inc.
Discuss GLP/ICH-compliant study design for your FIH submission.

To labcorp.
Call us

Pharmacokinetic (PK/PD) Studies
High-Precision Bioanalysis for Clinically Predictive PK/PD Evaluation

PhoenixBio Co., Ltd.

Source: PhoenixBio Co., Ltd. Official Website (https://phoenixbio.co.jp/)

PhoenixBio Co., Ltd.offers pharmacokinetic and hepatic metabolism studies using their proprietary PXB-mouse®, a humanized-liver chimeric mouse model. This platform enables the acquisition of data with high clinical correlation in ADME, drug–to-drug interaction studies, bridging the gap between preclinical and clinical stages.
With advanced LC-MS/MS-based bioanalysis, PhoenixBio Co., Ltd. provides aseamless workflow from plasma concentration measurement and metabolite identification to quantitative validation.
The company offersan integrated evaluation analysiscovering pharmacokinetics, hepatotoxicity, and safety with flexibility to accommodate complex modalities such as oligonucleotide and middle-molecule therapeutics. For compounds where hepatic metabolism is a development bottleneck—or where quantitative, reproducible exposure data are critical—PhoenixBio Co., Ltd. delivers unmatched analytical precision and consistency.

Consult Phoenix Bio for PK/PD analysis with a clinical focus

Phoenix Bio.
Call us