Nonclinical testing is an essential first step in new drug development. In this phase, the safety and efficacy of investigational compounds are assessed, establishing the foundation for subsequent clinical trials. The sections below outline drug discovery efforts and the role of nonclinical testing for each disease area.
New Anticancer Drugs
Oncology drug discovery is a critical effort to develop therapies for the intractable disease of cancer. Nonclinical studies use animal models to assess the efficacy and safety of investigational agents. These studies aim to address significant unmet needs for patients.
New Drugs for Immune Diseases
Immune diseases occur when the immune system mistakenly attacks the body’s own tissues. Through nonclinical studies, researchers evaluate the efficacy of new drug candidates and establish the basis for subsequent clinical trials. Advancing these programs may improve patient outcomes.
Drug Discovery for the Treatment of Organ Fibrosis
Organ fibrosis is a serious condition affecting major organs such as the liver, lungs, and kidneys. Data generated in nonclinical studies are critical to support advancement to clinical studies. Successful drug development could substantially improve patients’ quality of life.
Drug Discovery for Retinal Neurodegenerative Diseases
Retinal neurodegenerative diseases are serious conditions that can lead to visual impairment. Nonclinical studies evaluate the safety and efficacy of new agents and investigate potential effects on visual function. Ongoing research and innovation are expected to enable new therapeutic options.
R&D in Neurodegenerative Diseases
Neurodegenerative diseases are characterized by the gradual loss of function in brain and nerve cells. Nonclinical studies verify efficacy and safety to enable progression to clinical trials. These efforts aim to advance treatments for Alzheimer’s disease, Parkinson’s disease, and related conditions.
R&D in Metabolic Diseases
Nonclinical testing is essential to drug discovery for metabolic diseases. These studies help establish the efficacy and safety of investigational agents and support the development of better treatment options. The role of nonclinical studies continues to grow as research advances.
Drug Discovery for Atopic Dermatitis and Other Allergic Diseases
Atopic dermatitis is a skin disease characterized by chronic inflammation and intense itching. Through nonclinical studies, the efficacy and safety of new agents are evaluated to inform more effective treatments. Continued drug development may improve patients’ quality of life.
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