In non-clinical development, the choice of contract research organization shapes the quality of the data and the time it takes to reach the next decision. Below, three CROs are introduced by the type of study they support: pharmacology (efficacy) studies, safety studies, and pharmacokinetic (PK/PD) studies. Each summary describes the services the company offers so that you can match a provider to your target and development objective.
SMC Laboratories is a specialized non-clinical CRO focused on in vivo pharmacology and efficacy studies using disease-relevant animal models, particularly in fibrosis, inflammation, metabolic diseases, and oncology.
SMC Laboratories offers models covering the liver, lung, kidney, intestine, and oncology. Its portfolio includes the proprietary STAM™ model for MASH, fibrosis, and hepatocellular carcinoma.
Study plans are developed around the target biology, mechanism of action, disease stage, and development objective. Pharmacological endpoints can be combined with histopathology, biomarkers, and disease-specific readouts.
With experience from more than 1,000 studies for clients in 30 countries, SMC Laboratories supports programs from target validation and candidate selection through in vivo proof-of-concept studies.
SMC Group International, Inc., our U.S.-based group company, serves as the primary point of contact for clients in the United States.
Charles River provides non-clinical toxicology and safety assessment services for programs ranging from exploratory safety studies to IND-enabling development.
Services include single- and repeat-dose toxicology, dose-range finding, and general toxicology studies across multiple species and administration routes.
Charles River supports both non-GLP and GLP studies, allowing sponsors to progress from early safety characterization to studies intended for regulatory submissions.
Toxicology studies can be integrated with toxicokinetics, clinical pathology, histopathology, and safety pharmacology to support interpretation and IND-enabling safety packages.
Inotiv provides integrated PK/PD, DMPK, and bioanalytical services to characterize drug exposure and its relationship with pharmacological response.
PK studies characterize exposure, half-life, clearance, and other pharmacokinetic parameters needed to understand how a candidate behaves in the selected model.
Pharmacokinetic data can be combined with pharmacodynamic endpoints and bioanalysis to evaluate the relationship between drug exposure and pharmacological response.
Integrated DMPK, pharmacology, and safety information supports candidate comparison, dose selection, dosing-frequency optimization, and decisions about subsequent preclinical development.
Here, we introduce contract research organizations (CROs) and agencies that provide non-clinical study outsourcing and support services. Each company’s unique technologies, specialized models, and case studies are summarized in detail to help you select the most suitable partner for your nonclinical research needs.
Serving over 1,000 pharmaceutical and biotech companies across 30 countries, SMC Laboratories, Inc. offers extensive consulting and research support for efficacy evaluation studies. Their highly advanced patented technologies and well-equipped facilities enable high-quality nonclinical study outsourcing.
See Details of SMC Laboratories, Inc.’ Nonclinical Study Services
Alpha Genesis, Inc. is a preclinical research organization and animal resource supplier in Yemassee, South Carolina.Pharmacology and PK/PDThe company describes "efficacy, mechanism-of-action, dose-response, PK sampling, and PD biomarker studies in rodent and NHP models, with GLP and non-GLP support for IND programs."
See Details of Alpha Genesis’ Nonclinical Study Services
Battelle Memorial Institute is an independent nonprofit applied science and technology organization in Columbus, Ohio, which states that it has served government and industry "since its founding in 1929."Biocontainment and medical countermeasuresOne documented capability is high-containment infectious disease and countermeasure work.
See Details of Battelle’s Nonclinical Study Services
BioAgilytix Labs, Inc. is a bioanalytical laboratory headquartered in the Research Triangle area of North Carolina.Pharmacokinetics, immunogenicity, and biomarkersThe solutions page lists drug metabolism, pharmacokinetic services, pharmacodynamics, immunogenicity, biomarkers and diagnostic testing as the service lines.
See Details of BioAgilytix’s Nonclinical Study Services
BioDuro is a contract research, development and manufacturing organization headquartered in Irvine, California.Discovery, DMPK and in vivo pharmacologyThe discovery offering spans medicinal and process chemistry, discovery biology, monoclonal antibody discovery, drug metabolism and pharmacokinetics, and in vivo pharmacology, distributed across the China sites.
See Details of BioDuro’s Nonclinical Study Services
BioIVT supplies the biological material that in vitro work is run on, and also lists laboratory services on its current website.Biospecimens and primary cellsThe company describes itself as providing control and disease-state samples, including human and animal tissues, products for absorption, distribution, metabolism, excretion and toxicity work, and biofluids.
See Details of BioIVT’s Nonclinical Study Services
Biomere is a preclinical contract research organization in Worcester, Massachusetts that presents itself as "A JOINN Company."Key capabilitiesSee the company profile for available services and project-specific capabilities.
See Details of Biomere (JOINN Biomere)’s Nonclinical Study Services
BioModels, LLC is a preclinical contract research organization (CRO) in Waltham, Massachusetts.Efficacy studies in rodent disease modelsThe company's work centers on efficacy studies in mouse and rat models.
See Details of BioModels’ Nonclinical Study Services
BIOQUAL, Inc. is a nonclinical contract research organization in Rockville, Maryland.Infectious disease modelsThe company lists infectious disease models and biosafety level 3 capabilities.
See Details of BIOQUAL’s Nonclinical Study Services
CBSET, Inc. is a preclinical translational research organization in Lexington, Massachusetts, founded in 2006 and formally named Concord Biomedical Sciences and Emerging Technologies, Inc. It describes itself as a preclinical translational research institute rather than a conventional contract laboratory.Implanted devices and combination productsDevice work is described as running from early iteration and mechanistic studies through to large-scale GLP safety assessments, supported by operating suites and several imaging modalities.
See Details of CBSET, Inc.’s Nonclinical Study Services
Certis Oncology Solutions, Inc. is an oncology company in the Sorrento Valley district of San Diego, California, founded in 2016.Orthotopic patient-derived xenograft studiesThe company describes efficacy testing in orthotopic patient-derived xenograft models, abbreviated O-PDX, which the company abbreviates as O-PDX.
See Details of Certis Oncology Solutions, Inc.’s Nonclinical Study Services
Champions Oncology, Inc. (Nasdaq: CSBR) is an oncology-focused contract research organization headquartered in Hackensack, New Jersey, with laboratory operations in Rockville, Maryland.Service linesThe services page groups the offering into in vivo models, ex vivo platforms, and clinical specialty testing.
See Details of Champions Oncology’s Nonclinical Study Services
Charles River Laboratories International, Inc. (NYSE: CRL) is a Wilmington, Massachusetts-based provider of research models and nonclinical drug development services.IND-enabling program supportCharles River positions its Safety Assessment business around complete Investigational New Drug (IND)-enabling programs as well as stand-alone studies.
See Details of Charles River Laboratories’ Nonclinical Study Services
CorDynamics is a preclinical contract research organization in the Illinois Medical District in Chicago that works only on cardiovascular questions.Atrial fibrillation and heart failureThe atrial fibrillation panel uses rat, guinea pig and large animal species, with three model formats: "isolated Langendorff heart; anesthetized large animal (acute vagal pacing); telemetry-based chronic atrial tachypacing."
See Details of CorDynamics’ Nonclinical Study Services
Crown Bioscience, Inc. is an oncology-focused contract research organization headquartered in San Diego, California, founded in 2006.Key capabilitiesSee the company profile for available services and project-specific capabilities.
See Details of Crown Bioscience’s Nonclinical Study Services
Experimental Pathology Laboratories, Inc., which uses the trademark EPL, is a toxicologic pathology specialist in Sterling, Virginia.Pathology and peer reviewPathology is the core line, covering histopathology evaluation, pathology peer review, Pathology Working Groups, carcinogenicity and chronic study pathology, transmission electron microscopy and research animal model support.
See Details of Experimental Pathology Laboratories (EPL)’s Nonclinical Study Services
Frontage Laboratories is a contract research organization headquartered in Exton, Pennsylvania, founded in 2001 and incorporated in Pennsylvania in 2004.Bioanalysis and drug metabolismBioanalysis covers small and large molecules through chromatography with mass spectrometry, ligand binding assays, flow cytometry and immunogenicity testing, supporting pharmacokinetic and toxicokinetic studies, drug interaction work, bioavailability and bioequivalence, protein binding and biomarkers.
See Details of Frontage Laboratories, Inc.’s Nonclinical Study Services
Hesperos, Inc. is a contract research organization in Orlando, Florida that describes contract research services using human cells in interconnected microfluidic systems.Cardiotoxicity, hepatotoxicity, and cardiac electrophysiologyThe base two-organ heart and liver system is used for acute and chronic cardiotoxicity and hepatotoxicity screening, with the company stating that systems are "routinely operated up to 28 days."
See Details of Hesperos’ Nonclinical Study Services
Hooke Laboratories, LLC is a preclinical contract research organization (CRO) in Lawrence, Massachusetts, about 30 minutes north of Boston.A single-focus model menuThe company's service list is limited to inflammation and autoimmunity.
See Details of Hooke Laboratories’ Nonclinical Study Services
IBT Bioservices is the contract research business of Integrated Biotherapeutics, LLC, based at 4 Research Court in Rockville, Maryland.In vivo infectious disease modelsThe company states that it "provides full-service preclinical in vivo testing services with 15+ established animal models for drug and vaccine development."
See Details of IBT Bioservices’ Nonclinical Study Services
Ichor Life Sciences, Inc. describes itself as "a pre-clinical contract research organization (CRO) with 100% US operations."In vivo disease modelsThe in vivo model catalog spans oncology and immuno-oncology, ophthalmology, aging and lifespan, metabolic disease, wound healing, cardiovascular disease and custom model development.
See Details of Ichor Life Sciences’ Nonclinical Study Services
IIT Research Institute, known as IITRI, is a nonclinical contract research organization in Chicago, Illinois.Toxicology and carcinogenicityThe company describes itself as "a high-quality provider of preclinical toxicology and drug safety evaluation services in accordance with GLP standards, with over 40 years of experience."
See Details of IIT Research Institute (IITRI)’s Nonclinical Study Services
Inotiv, Inc. (Nasdaq: NOTV) is a nonclinical contract research organization (CRO) headquartered in West Lafayette, Indiana.Discovery through IND-enabling supportInotiv reports two business segments: Discovery and Safety Assessment (DSA) and Research Models and Services (RMS).
See Details of Inotiv’s Nonclinical Study Services
InVivo Biosystems is a contract research organization in Eugene, Oregon whose reviewed model pages focus on two non-mammalian species, the zebrafish (Danio rerio) and the nematode C.Model generation with CRISPRThe company offers custom zebrafish and C.
See Details of InVivo Biosystems’ Nonclinical Study Services
The Jackson Laboratory, known as JAX, is an independent nonprofit biomedical research institution headquartered in Bar Harbor, Maine.Efficacy, pharmacokinetic, and safety studiesJAX states that "JAX Preclinical Services offers the most translational and predictive efficacy, pharmacokinetics (PK) and safety testing for therapeutics such as monoclonal antibodies, bispecifics, CAR-T, antibody-drug conjugates, and combination therapies."
See Details of The Jackson Laboratory (JAX)’s Nonclinical Study Services
KCAS Bio describes itself as "a full-service bioanalytical and biomarker contract research organization (CRO) that helps pharmaceutical and biotech sponsors move drug candidates from discovery through clinical development."Small and large molecule bioanalysisFor small molecules the company states that it "provides GLP/GCP-compliant small molecule bioanalysis, using advanced LC-MS/MS platforms to quantify drugs, metabolites, and biomarkers from discovery through clinical stages."
See Details of KCAS Bio’s Nonclinical Study Services
LifeCanvas Technologies is a tissue clearing and light-sheet imaging company in Cambridge, Massachusetts, founded by Kwanghun Chung of the Massachusetts Institute of Technology.What is and is not in scopeThe contract services are whole-organ tissue clearing, immunolabeling, imaging and analysis, performed on paraformaldehyde-fixed material supplied by the client.
See Details of LifeCanvas Technologies’ Nonclinical Study Services
Lovelace Biomedical is a not-for-profit nonclinical contract research organization (CRO) in Albuquerque, New Mexico.Service lines and specialty areasThe company lists seven specialty areas: respiratory, infectious disease, gene therapy, neuroscience, alternative tobacco and cannabis products, medical countermeasures, and animal health.
See Details of Lovelace Biomedical’s Nonclinical Study Services
MB Research Laboratories is a contract laboratory in Pennsylvania that describes itself as "a leading Contract Research Organization (CRO) based in Pennsylvania, specializing in short-term toxicology and pharmacology testing services since 1972."Acute toxicology and genotoxicityThe regulatory toxicology line covers acute oral toxicity under OECD Test Guideline 425, acute dermal toxicity under OECD 402, acute inhalation toxicity under OECD 403 and EPA OCSPP 870.
See Details of MB Research Laboratories’ Nonclinical Study Services
MD Biosciences is a preclinical contract research organization built around pain and the central nervous system, working in rodents and, in rodents and pigs.Pain modelsThe company lists inflammatory, neuropathic and surgical pain models.
See Details of MD Biosciences’ Nonclinical Study Services
Melior Discovery, Inc. is an in vivo pharmacology contract research organization in Exton, Pennsylvania.Phenotypic screening platformsThe company's platform theraTRACE, which it describes as its proprietary phenotypic screening platform, is, described as "Melior's proprietary phenotypic screening platform" for identifying "new therapeutic applications for your candidate with our customizable multiplexed array of animal models."
See Details of Melior Discovery’s Nonclinical Study Services
MuriGenics is a preclinical contract research organization in Vallejo, California, on the northeast side of San Francisco Bay.Oncology and immuno-oncology modelsThe oncology page lists xenograft, syngeneic, orthotopic, homograft, genetically engineered and metastatic mouse models, grouped as xenograft (cell line-derived), syngeneic, orthotopic, homograft and genetically engineered mouse models, and metastatic models.
See Details of MuriGenics’ Nonclinical Study Services
NAMSA is a contract research organization in Northwood, Ohio, that describes itself as 100% focused on medical devices and in vitro diagnostics.Preclinical animal studies for devicesThe named study categories are organized by anatomy and procedure rather than by drug development phase: cardiovascular and cardiothoracic, neurovascular, vascular, thrombosis and thromboresistance, hemostasis, orthopedic, dental, dermal, ophthalmic, pulmonary, gastrointestinal, urogenital, electrophysiology and wound healing studies.
See Details of NAMSA’s Nonclinical Study Services
Nelson Laboratories, LLC, which trades as Nelson Labs, is a testing laboratory in Salt Lake City, Utah and a business of Sotera Health Company (Nasdaq: SHC).Biocompatibility and toxicology under ISO 10993Biocompatibility is the biocompatibility service line.
See Details of Nelson Labs’ Nonclinical Study Services
Noble Life Sciences is a preclinical contract research organization (CRO) located in Sykesville, Maryland.Efficacy models: oncology, infectious disease, and metabolic diseaseThe Therapeutics section of the website lists oncology models (syngeneic mouse models, patient-derived xenograft (PDX), xenograft, and orthotopic tumor models) with study areas in immuno-oncology, vaccines, small molecules, and cell and gene therapy; infectious disease efficacy testing for antiviral and antibacterial candidates and vaccines, including work…
See Details of Noble Life Sciences’ Nonclinical Study Services
OSOD, LLC, trading as Ocular Services On Demand, is an ophthalmic specialist in Madison, Wisconsin.Study design, program strategy, and monitoringThe preclinical discovery service is framed around access and advice rather than bench execution: the company offers to "provide access to the relevant and translatable efficacy models" and gives "guidance on formulation" alongside non-GLP ocular safety and tolerability work and pharmacokinetic and ocular distribution studies.
See Details of Ocular Services On Demand (OSOD)’s Nonclinical Study Services
Pacific BioLabs is a testing laboratory in Hercules, California.Medical device biocompatibility and sterility assuranceFor medical devices the company lists in vivo biocompatibility, USP Class Plastics testing, material-mediated pyrogenicity and contact lens solution testing.
See Details of Pacific BioLabs’ Nonclinical Study Services
Product Safety Labs is an independent contract laboratory in Dayton, New Jersey, established in 1972 and operating from a single site.ToxicologyThe toxicology programme covers acute studies by oral, dermal and inhalation routes, eye and skin irritation, skin sensitization by local lymph node assay and by the Buehler and maximization methods, repeat-dose and subchronic studies across several routes, chronic and carcinogenicity study designs, and reproductive and developmental toxicology from…
See Details of Product Safety Labs, LLC’s Nonclinical Study Services
PsychoGenics Inc. is a preclinical contract research organization (CRO) based in Paramus, New Jersey.In vivo CNS pharmacology and behavioral testingThe company's service pages present in vivo work built around behavioral assays in mice and rats, with in-house support functions that it says let a sponsor "keep your project under one roof."
See Details of PsychoGenics’ Nonclinical Study Services
QPS Holdings, LLC is a contract research organization headquartered in the Delaware Technology Park in Newark, Delaware.BioanalysisBioanalysis is the company's original service line.
See Details of QPS’ Nonclinical Study Services
Resolian is a bioanalysis and drug metabolism laboratory headquartered in Malvern, Pennsylvania.What is and is not in scopeNo toxicology, safety pharmacology, pathology, infectious disease or medical device testing service line was found on the company website.
See Details of Resolian Inc. (formerly Alliance Pharma)’s Nonclinical Study Services
Smithers describes itself as "a multinational provider of testing, consulting, information, and compliance services" and traces its founding to a three-bay garage in Akron, Ohio in 1925.Large-molecule bioanalysis and immunogenicityThe pharmaceutical business is built on large-molecule bioanalysis.
See Details of Smithers’ Nonclinical Study Services
Southern Research is a research organization in Birmingham, Alabama that offers contract research services for drug development.Infectious disease research and FDA Animal Rule studiesSouthern Research describes "secure, compliant BSL-3 facilities to handle select agents and emerging infectious threats" and lists FDA Animal Rule studies, vaccine efficacy and immunogenicity testing at BSL-2 and BSL-3, and GCLP-compliant clinical trial sample analysis among its infectious disease services.
See Details of Southern Research’s Nonclinical Study Services
SRI International is an independent nonprofit research institute in Menlo Park, California.DMPK, ADME, and bioanalysisThe institute states that it "offers comprehensive drug metabolism and pharmacokinetic (DMPK) services to meet your needs" and that its "PK studies that meet all U.S. and European IND submission requirements."
See Details of SRI International (SRI Biosciences)’s Nonclinical Study Services
StageBio is a histopathology contract research organization headquartered in Frederick, Maryland.Histology and toxicologic pathologyHistology covers necropsy support, tissue processing, embedding, sectioning and slide production, with the company stating that "our histology services and facilities are GLP-compliant" and listing bone decalcification and oversized tissue processing in paraffin and plastics among its capabilities.
See Details of StageBio’s Nonclinical Study Services
Surpass, Inc. is a preclinical contract research organization in the greater Twin Cities area, near the medical device cluster around Minneapolis and St. Paul.Surgical and interventional in vivo studiesThe company organizes its work around eleven named clinical areas: cardiac covering structural heart and electrophysiology, dermal, gastrointestinal, general and reconstructive surgery, neurological, oncology, orthopedic and spine, respiratory, urogenital, vascular, and wound healing and traumatic injury, plus a track for de novo and disruptive technologies.
See Details of Surpass’ Nonclinical Study Services
T3 Labs is a preclinical laboratory in Atlanta, Georgia, and since December 14, 2023 it has been part of Veranex, a contract research organization focused on medical devices and diagnostics.Species and modelsLarge animal models are the centre of the offering: swine, both farm breeds and minipigs, sheep, cattle and goats, with mice, rats, rabbits and guinea pigs available for smaller-scale work.
See Details of T3 Labs (a Veranex facility)’s Nonclinical Study Services
Taconic Biosciences supplies the animals that other laboratories run studies in.Model supply and custom model generationCustom models are generated by gene editing, embryonic stem cell targeting and pronuclear injection, with a doctoral-level project manager assigned to each programme, and the company states it has produced roughly 5,000 custom models over the last fifteen years.
See Details of Taconic Biosciences, Inc.’s Nonclinical Study Services
TD2, which stands for Translational Drug Development, is an oncology-focused organization in Scottsdale, Arizona.In vivo oncology modelsThe preclinical offering covers in vivo tumor models including syngeneic models, patient-derived xenografts, cell line-derived xenografts and humanized mouse models, run in a facility the company describes as AAALAC accredited.
See Details of TD2 (Translational Drug Development)’s Nonclinical Study Services
Texas Biomedical Research Institute is an independent nonprofit research institute in San Antonio, Texas, founded in 1941 and operating from a single 200-acre campus with more than 360 staff.Key capabilitiesSee the company profile for available services and project-specific capabilities.
See Details of Texas Biomedical Research Institute’s Nonclinical Study Services
Translucence Biosystems, Inc. is a tissue clearing and whole-brain imaging company in Irvine, California, founded in 2018 as a spin-out of the Sunil Gandhi laboratory at the University of California, Irvine.What is sold as a productThe product line covers the Mesoscale Imaging System, described as a modified light-sheet microscope built on a ZEISS platform; Stitchy, an image stitching software tool; and three tissue clearing kits priced between about 895 and 995 US dollars.
See Details of Translucence Biosystems’ Nonclinical Study Services
TransPharm Preclinical Solutions, Inc. is a small infectious disease specialist in Jackson, Michigan.In vivo infection models and in vitro microbiologyThe company runs efficacy models of infection in mice and rats, with pharmacokinetic blood sampling available alongside the efficacy readouts.
See Details of TransPharm Preclinical Solutions’ Nonclinical Study Services
Yecuris supplies liver-humanized mice and human hepatocytes from a facility in the Portland area of Oregon, and runs studies on that platform.FRG KO liver-humanized miceThe FRG designation refers to a triple knockout of Fah, Rag2 and Il2rg on a C57BL/6 background, which the company states was originally reported by Azuma and colleagues in 2007.
See Details of Yecuris Corporation’s Nonclinical Study Services
| CRO Name | Official HP URL |
|---|---|
| Abogen Biosciences | https://abogenbio.com/ |
| Absorption Systems | https://cro-preclinical.com/ |
| Accelera Srl | https://www.accelera.org/ |
| Accutest Research Laboratories | https://www.accutestglobal.com/ |
| Agno Pharma | https://agnopharma.com/ |
| AIT Bioscience | https://labs.iqvia.com/ |
| Alcanza Clinical Research | https://alcanzaclinical.com/ |
| Algorithme Pharma Inc. | https://www.altasciences.com/preclinical-research-services |
| AlpalifeBio | https://www.alpalifebio.com/ |
| Altasciences | https://www.altasciences.com/ |
| American Preclinical Services | https://namsa.com/ja/namsa/american-preclinical-aps/ |
| Aragen Bioscience | https://www.aragen.com/ |
| Ardena | https://ardena.com/ |
| Asan Medical Center Clinical Trial Center | https://eng.amc.seoul.kr/gb/lang/index.do |
| Asymchem Laboratories | https://www.asymchem.com/ |
| Atlantic Research Group | https://atlanticresearchgroup.com/ |
| Aurigene Pharmaceutical Services | https://www.aurigeneservices.com/ |
| Avance Clinical Pty Ltd. | https://www.avancecro.com/ |
| Axis Clinicals Pvt. Ltd. | https://axisclinicals.com/ |
| Axxam SpA | https://axxam.com/ |
| BASi Research Products | https://www.basinc.com/products |
| Bellberry Limited | https://bellberry.com.au/ |
| BGI Genomics Singapore Pte Ltd. | https://www.bgi.com/global |
| BioAgilytix | https://www.bioagilytix.com/ |
| Bioclever | https://astrumcro.com/ |
| Bioclinica | https://bioclinica.ro/ |
| Biodextris Inc. | https://www.biodextris.com/ |
| Bioforum Ltd. | https://bioforumgroup.com/ |
| BioInno CRO Services | https://new.bioinnobio.com/ |
| BioLASCO Taiwan Co. | https://www.biolasco.com.tw/en/ |
| BioLizard | https://lizard.bio/ |
| Bioneeds India Pvt. Ltd. | https://www.bioneeds.in/ |
| Bioneer A/S | https://bioneer.dk/ |
| Bionet Co. | https://ebionet.com/ |
| BioOutsource Ltd. | https://www.sartorius.com/en/pr/biooutsource-integration |
| Biotoxtech Co. Ltd. | http://eng.biotoxtech.com/ |
| BML Inc. | https://www.bml.co.jp/ |
| Boji Medical Biotechnological | https://www.bojicro.com/ |
| Borealis Biosciences CRO | https://www.borealisbio.com/ |
| BRI Biopharmaceutical Research Inc. | https://www.frontagelab.com/ |
| C&R Research Inc. | https://www.cnrres.com/ |
| Catalent Pharma Solutions | https://japan.catalent.com/ |
| Cato Research Israel Ltd. | https://www.catonetworks.com/ |
| Celerion | https://www.celerion.com/ |
| Center for Drug Evaluation | https://www.cde.org.tw/ |
| CHA Bundang Medical Center Clinical Trial Center | http://bundang.chamc.co.kr/ |
| Charles River Laboratories, Inc. | https://www.criver.com/ |
| ChemExpress | http://www.chemexpress.com.cn/ |
| ChemOn Inc. | http://www.chemon.co.kr/ |
| Citruslabs | https://www.citruslabs.com/ |
| Clario. | https://clario.com/ |
| CLEA Japan, Inc. | https://www.clea-japan.com/ |
| Cliantha Research Ltd. | https://www.cliantha.com/ |
| ClinChoice | https://www.clinchoice.com/ |
| ClinEdge | https://www.clin-edge.com/ |
| Clinials Pty Ltd. | https://www.clinials.com/ |
| Cliniexperts Research Pvt. Ltd. | https://cliniexperts.com/ |
| Clininvent Research Pvt. Ltd. | https://www.tcgls.com/ |
| CluePoints | https://cluepoints.com/ |
| CMG Pharmaceutical Clinical CRO | http://www.cmgpharma.co.kr/ |
| CMIC HOLDINGS Co. | https://www.cmicgroup.com/ |
| Concept Life Sciences Ltd. | https://www.conceptlifesciences.com/ |
| Criterium Inc. | https://criteriuminc.com/ |
| CTI Clinical Trial & Consulting | https://www.ctifacts.com/ |
| Curia Global | https://curiaglobal.com/ |
| Cytel Canada Inc. | https://www.cytel.com/ |
| Cytel Inc. | https://www.cytel.com/ |
| Dabur Research Foundation | https://www.drf.co.in/ |
| Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) | https://www.dgmif.re.kr/ |
| DreamCIS Inc. | https://www.dreamcis.com/ |
| Emerald Clinical Trials Pty Ltd. | https://emeraldclinicaltrials.com.au/ |
| Enamine China | https://enamine.net/ |
| EPS Holdings Inc. | https://www.eps-holdings.co.jp/ |
| Ergomed | https://www.ergomedplc.com/ |
| Everest Clinical Research | https://www.ecrscorp.com/ |
| Evogene Ltd. | https://www.evogene.com/ |
| Evotec SE | https://www.evotec.com/ |
| Excelya SAS | https://www.excelya.com/ |
| Experimental Drug Development Centre (EDDC) | https://www.eddc.sg/ |
| FGK Clinical Research GmbH | https://www.fgk-cro.com/ |
| FHI Clinical | https://www.fhiclinical.com/ |
| Frontage Laboratories | https://www.frontagelab.com/ |
| Frontier Biotechnologies | http://www.frontierbiotech.com/ |
| GCP ClinPlus | https://www.clinplus.com/ |
| Genedata AG | https://www.genedata.com/ |
| Génome Québec Innovation Centre | https://www.genomequebec.com/ |
| Genomics BioSci & Tech Co. | https://www.genomics.com.tw/ |
| GenOway Europe GmbH | https://www.genoway.com/ |
| GenScript | https://www.genscript.com/ |
| George Clinical Pty Ltd. | https://www.georgeclinical.com/ |
| George Clinical Singapore Pte Ltd. | https://www.georgeclinical.com/ |
| Aitia | https://aitia.ai/ |
| Green Cross Laboratories | https://www.gclabs.co.kr/ |
| Gsap CRO Ltd. | https://www.gsap.co.il/ |
| Gubra A/S | https://www.gubra.dk/ |
| GVRP | https://gvrp.org/ |
| HitGen | https://www.hitgen.com/ |
| hVIVO | https://hvivo.com/ |
| Hybrigenics Services SAS | https://www.hybrigenics-services.com/ |
| ICE Bioscience | http://www.ice-biosci.com/ |
| ICON plc | https://www.iconplc.com/ |
| IDDI | https://www.iddi.com/ |
| Indegene Pvt. Ltd. | https://www.indegene.com/ |
| Indero Inc. | https://indero.com/ |
| Innostar Biotech | http://www.shinnostar.com/ |
| Innovaderm Research Inc. | https://innovaderm.com/ |
| IQVIA | https://www.iqvia.com/ |
| Jackson Laboratory | https://www.jax.org/ |
| Japan SLC Inc. | https://www.jslc.co.jp/ |
| Jubilant Biosys Ltd. | https://www.jubilantbiosys.com/ |
| KAC Co. Ltd. | https://www.kacnet.co.jp/ |
| KCAS Bioanalytical | https://kcasbio.com/ |
| KCR CRO GmbH | https://www.kcrcro.com/ |
| Keyrus Life Science France | https://keyruslifescience.com/ |
| KLIFO A/S | https://klifo.com/ |
| KNOTUS Co. | https://www.hlbbiostep.com/ |
| Korea Nonclinical Technology Center | http://www.konontech.com/ |
| Korea University Clinical Trial Center | https://kumcctc.or.kr/ |
| Kymos Group | https://www.kymos.com/ |
| LAB to Market Inc. | http://www.labtomarket.co.kr/ |
| Fortrea | https://www.fortrea.com/ |
| LGC Group | https://www.lgcgroup.com/ |
| Linear Clinical Research Ltd. | https://www.linear.org.au/ |
| Linical Co. | https://www.linical.co.jp/ |
| Liveon Biolabs Pvt. Ltd. | https://liveonbiolabs.com/ |
| Lotus Clinical Research Academy | https://www.lotuscro.com/ |
| LSK Global Pharma Services Co. | http://www.lskglobal.com/ |
| MAC Clinical Research | https://www.macclinicalresearch.com/ |
| Macrogen Inc. | https://www.macrogen.com/ |
| MakroCare Clinical Research | https://www.makrocare.com/devices/clinical/cro-services/ |
| Medelis | https://medelis.com/ |
| Medical & Biological Laboratories Co. | https://www.mbl.co.jp/ |
| Medical Edge Co. | http://www.medicaledge.jp/ |
| Medicilon Preclinical | https://www.medicilon.com/ |
| Medicilon Safety Evaluation Center | https://www.medicilon.com/ |
| Medistat Ltd. | https://www.medistat.co.il/ |
| Meditrial Europe Ltd. | https://www.meditrial.net/ |
| Medpace Holdings | https://www.medpace.com/ |
| AdBio | https://www.adbiocp.com/ |
| Merck BioReliance Services GmbH | https://www.bioreliance.com/ |
| Microcoat Biotechnologie GmbH | https://www.microcoat.de/ |
| Mitsubishi Chemical Research Corporation | https://www.m-chemres.co.jp/ |
| Micron Inc. | https://www.micron-kobe.com/ |
| NAMSA | https://namsa.com/ |
| Nanjing CR Medicon | http://www.crmedicon.com/ |
| NeoGenomics | https://neogenomics.com/ |
| Nordic Bioscience | https://www.nordicbioscience.com/ |
| Novotech | https://novotech-cro.com/ |
| Nucleus Network Pty Ltd. | https://www.nucleusnetwork.com/ |
| Nucro-Technics Inc. | https://nucro-technics.com/ |
| Nuvisan GmbH | https://www.nuvisan.com/ |
| O2h Discovery | https://o2h.com/ |
| Obio Technology Shanghai | http://www.obiogps.com/ |
| Oncodesign Services SAS | https://www.oncodesign-services.com/ |
| Oncologica UK Ltd. | https://oncologica.com/ |
| OPIS Srl | https://www.opis.it/ |
| Optimapharm France | https://www.optimapharm.eu/ |
| Pace Analytical Life Sciences | https://www.pacelabs.com/ |
| Parexel | https://www.parexel.com/ |
| PharmaBio Corporation | https://www.pharmabio.co.jp/ |
| PharmaBlock Sciences | https://www.pharmablock.com/ |
| PharmaEngine Inc. | https://www.pharmaengine.com/ |
| Pharmaron | https://www.pharmaron.com/ |
| Phenovista Biosciences Inc. | https://phenovista.com/ |
| PhoenixBio Co. | https://www.phoenixbio.co.jp/ |
| Pivotal CRO | https://pivotalcr.com/ |
| Porton Pharma Solutions | https://www.porton.cn/ |
| Precision for Medicine | https://www.precisionformedicine.com/ |
| Preclinical Research Center Co. | https://www.pre-clinical.co.jp/ |
| PRISYS Biotech | https://www.prisysbiotech.com/ |
| Prometrika | https://www.prometrika.com/ |
| Prometrika Canada Inc. | https://www.prometrika.com/ |
| ProteinTech Japan | https://www.ptglab.co.jp/ |
| PSI CRO | https://www.psi-cro.com/ |
| Q Clinical Research Ltd. | https://qclinicalresearch.com/ |
| QPS | https://www.qps.com/ |
| Quotient Sciences | https://www.quotientsciences.com/ |
| R&G PharmaStudies | http://www.rg-pharma.com/ |
| Reaction Biology Europe GmbH | https://www.reactionbiology.com/ |
| Rho Inc. | https://www.rhoworld.com/ |
| Richmond Pharmacology | https://www.richmondpharmacology.com/ |
| Sahlgrenska CRO | https://scro.se/ |
| Sai Life Sciences Ltd. | https://www.sailife.com/ |
| Samsung Medical Center Clinical Trial Center | https://www.smcctc.com/ |
| Scientia Clinical Research Ltd. | https://www.scientiaclinicalresearch.com.au/ |
| ScinoPharm Taiwan Ltd. | https://www.scinopharm.com/ |
| Seegene Medical Foundation | http://www.seegenelabs.com/ |
| Sekisui Medical Co. | https://www.sekisuimedical.jp/ |
| Semler Research Center Pvt. Ltd. | http://www.semlerresearch.com/ |
| Seoul CRO Co. | http://www.seoulcro.co.kr/ |
| Seoul National University Hospital Clinical Trial Center | http://ctc.snuh.org/ |
| SGS Life Sciences | https://www.sgs.com/ |
| Shanghai Medicilon | https://www.medicilon.com/ |
| Shanghai Xin Gao Pharmaceutical Development | http://www.xingaopharma.com/ |
| Shin Nippon Biomedical Laboratories Ltd. | https://www.snbl.co.jp/ |
| Simbec-Orion | https://www.simbecorion.com/ |
| Sino Biological CRO services | https://www.sinobiological.com/ |
| Sintesi Research Srl | https://www.sintesiresearch.com/ |
| SIRO Clinpharm Pvt. Ltd. | https://www.siroclinpharm.com/ |
| Sivan Clinical Research Ltd. | http://sivan-research.com/ |
| SMC Laboratories Inc. | https://www.smclab.co.jp/ |
| SomaLogic CRO services | https://somalogic.com/ |
| Southern Star Research Pty Ltd. | https://southernstarresearch.com/ |
| SRL Inc. | https://www.srl-group.co.jp/ |
| Sugen Life Sciences | http://sugenlifesciences.com/ |
| Sundia MediTech | http://www.sundia.com/ |
| Syneos Health | https://www.syneoshealth.com/ |
| Taconic Biosciences | https://www.taconic.com/ |
| TCG Lifesciences | https://www.tcgls.com/ |
| Texcell SA | https://www.texcell.com/ |
| TFS HealthScience | https://www.tfshls.com/ |
| TheraIndx Lifesciences | https://theraindx.com/ |
| Tigermed. | https://www.tigermedgrp.com/ |
| Trans Genic Inc. | https://www.transgenic.co.jp/ |
| TransCure BioServices | https://www.transcurebioservices.com/ |
| Trial Form Support | https://www.tfshls.com/ |
| Trial Nation | https://trialnation.dk/ |
| TWT GmbH Science & Innovation | https://www.twt-gmbh.de/ |
| Vancouver Prostate Centre Translational Research | https://www.prostatecentre.com/ |
| Vedic Lifesciences Pvt. Ltd. | https://www.vediclifesciences.com/ |
| Veeda Clinical Research Ltd. | https://www.veedacr.com/ |
| Veristat | https://www.veristat.com/ |
| Vial CRO | https://vial.com/ |
| Vimta Labs Ltd. | https://www.vimta.com/ |
| Viva Biotech | https://www.vivabiotech.com/ |
| Walter and Eliza Hall Institute Research Services | https://www.wehi.edu.au/ |
| Worldwide Clinical Trials | https://www.worldwide.com/ |
In non-clinical development, the choice of contract research organization shapes the quality of the data and the time it takes to reach the next decision. Below, three CROs are introduced by the type of study they support: pharmacology (efficacy) studies, safety studies, and pharmacokinetic (PK/PD) studies. Each summary describes the services the company offers so that you can match a provider to your target and development objective.
SMC Laboratories is a specialized non-clinical CRO focused on in vivo pharmacology and efficacy studies using disease-relevant animal models, particularly in fibrosis, inflammation, metabolic diseases, and oncology.
SMC Laboratories offers models covering the liver, lung, kidney, intestine, and oncology. Its portfolio includes the proprietary STAM™ model for MASH, fibrosis, and hepatocellular carcinoma.
Study plans are developed around the target biology, mechanism of action, disease stage, and development objective. Pharmacological endpoints can be combined with histopathology, biomarkers, and disease-specific readouts.
With experience from more than 1,000 studies for clients in 30 countries, SMC Laboratories supports programs from target validation and candidate selection through in vivo proof-of-concept studies.
Charles River provides non-clinical toxicology and safety assessment services for programs ranging from exploratory safety studies to IND-enabling development.
Services include single- and repeat-dose toxicology, dose-range finding, and general toxicology studies across multiple species and administration routes.
Charles River supports both non-GLP and GLP studies, allowing sponsors to progress from early safety characterization to studies intended for regulatory submissions.
Toxicology studies can be integrated with toxicokinetics, clinical pathology, histopathology, and safety pharmacology to support interpretation and IND-enabling safety packages.
Inotiv provides integrated PK/PD, DMPK, and bioanalytical services to characterize drug exposure and its relationship with pharmacological response.
PK studies characterize exposure, half-life, clearance, and other pharmacokinetic parameters needed to understand how a candidate behaves in the selected model.
Pharmacokinetic data can be combined with pharmacodynamic endpoints and bioanalysis to evaluate the relationship between drug exposure and pharmacological response.
Integrated DMPK, pharmacology, and safety information supports candidate comparison, dose selection, dosing-frequency optimization, and decisions about subsequent preclinical development.