BioAgilytix Labs, Inc. is a bioanalytical laboratory headquartered in the Research Triangle area of North Carolina.Pharmacokinetics, immunogenicity, and biomarkersThe solutions page lists drug metabolism, pharmacokinetic services, pharmacodynamics, immunogenicity, biomarkers and diagnostic testing as the service lines.

BioDuro is a contract research, development and manufacturing organization headquartered in Irvine, California.Discovery, DMPK and in vivo pharmacologyThe discovery offering spans medicinal and process chemistry, discovery biology, monoclonal antibody discovery, drug metabolism and pharmacokinetics, and in vivo pharmacology, distributed across the China sites.

BioIVT supplies the biological material that in vitro work is run on, and also lists laboratory services on its current website.Biospecimens and primary cellsThe company describes itself as providing control and disease-state samples, including human and animal tissues, products for absorption, distribution, metabolism, excretion and toxicity work, and biofluids.

Biomere is a preclinical contract research organization in Worcester, Massachusetts that presents itself as "A JOINN Company."Key capabilitiesSee the company profile for available services and project-specific capabilities.

BioModels, LLC is a preclinical contract research organization (CRO) in Waltham, Massachusetts.Efficacy studies in rodent disease modelsThe company's work centers on efficacy studies in mouse and rat models.

BIOQUAL, Inc. is a nonclinical contract research organization in Rockville, Maryland.Infectious disease modelsThe company lists infectious disease models and biosafety level 3 capabilities.

CBSET, Inc. is a preclinical translational research organization in Lexington, Massachusetts, founded in 2006 and formally named Concord Biomedical Sciences and Emerging Technologies, Inc. It describes itself as a preclinical translational research institute rather than a conventional contract laboratory.Implanted devices and combination productsDevice work is described as running from early iteration and mechanistic studies through to large-scale GLP safety assessments, supported by operating suites and several imaging modalities.

Certis Oncology Solutions, Inc. is an oncology company in the Sorrento Valley district of San Diego, California, founded in 2016.Orthotopic patient-derived xenograft studiesThe company describes efficacy testing in orthotopic patient-derived xenograft models, abbreviated O-PDX, which the company abbreviates as O-PDX.

Champions Oncology, Inc. (Nasdaq: CSBR) is an oncology-focused contract research organization headquartered in Hackensack, New Jersey, with laboratory operations in Rockville, Maryland.Service linesThe services page groups the offering into in vivo models, ex vivo platforms, and clinical specialty testing.

Charles River Laboratories International, Inc. (NYSE: CRL) is a Wilmington, Massachusetts-based provider of research models and nonclinical drug development services.IND-enabling program supportCharles River positions its Safety Assessment business around complete Investigational New Drug (IND)-enabling programs as well as stand-alone studies.

CorDynamics is a preclinical contract research organization in the Illinois Medical District in Chicago that works only on cardiovascular questions.Atrial fibrillation and heart failureThe atrial fibrillation panel uses rat, guinea pig and large animal species, with three model formats: "isolated Langendorff heart; anesthetized large animal (acute vagal pacing); telemetry-based chronic atrial tachypacing."

Crown Bioscience, Inc. is an oncology-focused contract research organization headquartered in San Diego, California, founded in 2006.Key capabilitiesSee the company profile for available services and project-specific capabilities.

Experimental Pathology Laboratories, Inc., which uses the trademark EPL, is a toxicologic pathology specialist in Sterling, Virginia.Pathology and peer reviewPathology is the core line, covering histopathology evaluation, pathology peer review, Pathology Working Groups, carcinogenicity and chronic study pathology, transmission electron microscopy and research animal model support.

Frontage Laboratories is a contract research organization headquartered in Exton, Pennsylvania, founded in 2001 and incorporated in Pennsylvania in 2004.Bioanalysis and drug metabolismBioanalysis covers small and large molecules through chromatography with mass spectrometry, ligand binding assays, flow cytometry and immunogenicity testing, supporting pharmacokinetic and toxicokinetic studies, drug interaction work, bioavailability and bioequivalence, protein binding and biomarkers.

Hesperos, Inc. is a contract research organization in Orlando, Florida that describes contract research services using human cells in interconnected microfluidic systems.Cardiotoxicity, hepatotoxicity, and cardiac electrophysiologyThe base two-organ heart and liver system is used for acute and chronic cardiotoxicity and hepatotoxicity screening, with the company stating that systems are "routinely operated up to 28 days."

Hooke Laboratories, LLC is a preclinical contract research organization (CRO) in Lawrence, Massachusetts, about 30 minutes north of Boston.A single-focus model menuThe company's service list is limited to inflammation and autoimmunity.

IBT Bioservices is the contract research business of Integrated Biotherapeutics, LLC, based at 4 Research Court in Rockville, Maryland.In vivo infectious disease modelsThe company states that it "provides full-service preclinical in vivo testing services with 15+ established animal models for drug and vaccine development."

Ichor Life Sciences, Inc. describes itself as "a pre-clinical contract research organization (CRO) with 100% US operations."In vivo disease modelsThe in vivo model catalog spans oncology and immuno-oncology, ophthalmology, aging and lifespan, metabolic disease, wound healing, cardiovascular disease and custom model development.

IIT Research Institute, known as IITRI, is a nonclinical contract research organization in Chicago, Illinois.Toxicology and carcinogenicityThe company describes itself as "a high-quality provider of preclinical toxicology and drug safety evaluation services in accordance with GLP standards, with over 40 years of experience."

Inotiv, Inc. (Nasdaq: NOTV) is a nonclinical contract research organization (CRO) headquartered in West Lafayette, Indiana.Discovery through IND-enabling supportInotiv reports two business segments: Discovery and Safety Assessment (DSA) and Research Models and Services (RMS).

InVivo Biosystems is a contract research organization in Eugene, Oregon whose reviewed model pages focus on two non-mammalian species, the zebrafish (Danio rerio) and the nematode C.Model generation with CRISPRThe company offers custom zebrafish and C.

The Jackson Laboratory, known as JAX, is an independent nonprofit biomedical research institution headquartered in Bar Harbor, Maine.Efficacy, pharmacokinetic, and safety studiesJAX states that "JAX Preclinical Services offers the most translational and predictive efficacy, pharmacokinetics (PK) and safety testing for therapeutics such as monoclonal antibodies, bispecifics, CAR-T, antibody-drug conjugates, and combination therapies."

KCAS Bio describes itself as "a full-service bioanalytical and biomarker contract research organization (CRO) that helps pharmaceutical and biotech sponsors move drug candidates from discovery through clinical development."Small and large molecule bioanalysisFor small molecules the company states that it "provides GLP/GCP-compliant small molecule bioanalysis, using advanced LC-MS/MS platforms to quantify drugs, metabolites, and biomarkers from discovery through clinical stages."

LifeCanvas Technologies is a tissue clearing and light-sheet imaging company in Cambridge, Massachusetts, founded by Kwanghun Chung of the Massachusetts Institute of Technology.What is and is not in scopeThe contract services are whole-organ tissue clearing, immunolabeling, imaging and analysis, performed on paraformaldehyde-fixed material supplied by the client.

Lovelace Biomedical is a not-for-profit nonclinical contract research organization (CRO) in Albuquerque, New Mexico.Service lines and specialty areasThe company lists seven specialty areas: respiratory, infectious disease, gene therapy, neuroscience, alternative tobacco and cannabis products, medical countermeasures, and animal health.

MB Research Laboratories is a contract laboratory in Pennsylvania that describes itself as "a leading Contract Research Organization (CRO) based in Pennsylvania, specializing in short-term toxicology and pharmacology testing services since 1972."Acute toxicology and genotoxicityThe regulatory toxicology line covers acute oral toxicity under OECD Test Guideline 425, acute dermal toxicity under OECD 402, acute inhalation toxicity under OECD 403 and EPA OCSPP 870.

MD Biosciences is a preclinical contract research organization built around pain and the central nervous system, working in rodents and, in rodents and pigs.Pain modelsThe company lists inflammatory, neuropathic and surgical pain models.

Melior Discovery, Inc. is an in vivo pharmacology contract research organization in Exton, Pennsylvania.Phenotypic screening platformsThe company's platform theraTRACE, which it describes as its proprietary phenotypic screening platform, is, described as "Melior's proprietary phenotypic screening platform" for identifying "new therapeutic applications for your candidate with our customizable multiplexed array of animal models."

MuriGenics is a preclinical contract research organization in Vallejo, California, on the northeast side of San Francisco Bay.Oncology and immuno-oncology modelsThe oncology page lists xenograft, syngeneic, orthotopic, homograft, genetically engineered and metastatic mouse models, grouped as xenograft (cell line-derived), syngeneic, orthotopic, homograft and genetically engineered mouse models, and metastatic models.

NAMSA is a contract research organization in Northwood, Ohio, that describes itself as 100% focused on medical devices and in vitro diagnostics.Preclinical animal studies for devicesThe named study categories are organized by anatomy and procedure rather than by drug development phase: cardiovascular and cardiothoracic, neurovascular, vascular, thrombosis and thromboresistance, hemostasis, orthopedic, dental, dermal, ophthalmic, pulmonary, gastrointestinal, urogenital, electrophysiology and wound healing studies.

Nelson Laboratories, LLC, which trades as Nelson Labs, is a testing laboratory in Salt Lake City, Utah and a business of Sotera Health Company (Nasdaq: SHC).Biocompatibility and toxicology under ISO 10993Biocompatibility is the biocompatibility service line.

Noble Life Sciences is a preclinical contract research organization (CRO) located in Sykesville, Maryland.Efficacy models: oncology, infectious disease, and metabolic diseaseThe Therapeutics section of the website lists oncology models (syngeneic mouse models, patient-derived xenograft (PDX), xenograft, and orthotopic tumor models) with study areas in immuno-oncology, vaccines, small molecules, and cell and gene therapy; infectious disease efficacy testing for antiviral and antibacterial candidates and vaccines, including work…

OSOD, LLC, trading as Ocular Services On Demand, is an ophthalmic specialist in Madison, Wisconsin.Study design, program strategy, and monitoringThe preclinical discovery service is framed around access and advice rather than bench execution: the company offers to "provide access to the relevant and translatable efficacy models" and gives "guidance on formulation" alongside non-GLP ocular safety and tolerability work and pharmacokinetic and ocular distribution studies.

Pacific BioLabs is a testing laboratory in Hercules, California.Medical device biocompatibility and sterility assuranceFor medical devices the company lists in vivo biocompatibility, USP Class Plastics testing, material-mediated pyrogenicity and contact lens solution testing.

Product Safety Labs is an independent contract laboratory in Dayton, New Jersey, established in 1972 and operating from a single site.ToxicologyThe toxicology programme covers acute studies by oral, dermal and inhalation routes, eye and skin irritation, skin sensitization by local lymph node assay and by the Buehler and maximization methods, repeat-dose and subchronic studies across several routes, chronic and carcinogenicity study designs, and reproductive and developmental toxicology from…

PsychoGenics Inc. is a preclinical contract research organization (CRO) based in Paramus, New Jersey.In vivo CNS pharmacology and behavioral testingThe company's service pages present in vivo work built around behavioral assays in mice and rats, with in-house support functions that it says let a sponsor "keep your project under one roof."

QPS Holdings, LLC is a contract research organization headquartered in the Delaware Technology Park in Newark, Delaware.BioanalysisBioanalysis is the company's original service line.

Resolian is a bioanalysis and drug metabolism laboratory headquartered in Malvern, Pennsylvania.What is and is not in scopeNo toxicology, safety pharmacology, pathology, infectious disease or medical device testing service line was found on the company website.

Smithers describes itself as "a multinational provider of testing, consulting, information, and compliance services" and traces its founding to a three-bay garage in Akron, Ohio in 1925.Large-molecule bioanalysis and immunogenicityThe pharmaceutical business is built on large-molecule bioanalysis.

Southern Research is a research organization in Birmingham, Alabama that offers contract research services for drug development.Infectious disease research and FDA Animal Rule studiesSouthern Research describes "secure, compliant BSL-3 facilities to handle select agents and emerging infectious threats" and lists FDA Animal Rule studies, vaccine efficacy and immunogenicity testing at BSL-2 and BSL-3, and GCLP-compliant clinical trial sample analysis among its infectious disease services.

SRI International is an independent nonprofit research institute in Menlo Park, California.DMPK, ADME, and bioanalysisThe institute states that it "offers comprehensive drug metabolism and pharmacokinetic (DMPK) services to meet your needs" and that its "PK studies that meet all U.S. and European IND submission requirements."

StageBio is a histopathology contract research organization headquartered in Frederick, Maryland.Histology and toxicologic pathologyHistology covers necropsy support, tissue processing, embedding, sectioning and slide production, with the company stating that "our histology services and facilities are GLP-compliant" and listing bone decalcification and oversized tissue processing in paraffin and plastics among its capabilities.

Surpass, Inc. is a preclinical contract research organization in the greater Twin Cities area, near the medical device cluster around Minneapolis and St. Paul.Surgical and interventional in vivo studiesThe company organizes its work around eleven named clinical areas: cardiac covering structural heart and electrophysiology, dermal, gastrointestinal, general and reconstructive surgery, neurological, oncology, orthopedic and spine, respiratory, urogenital, vascular, and wound healing and traumatic injury, plus a track for de novo and disruptive technologies.

T3 Labs is a preclinical laboratory in Atlanta, Georgia, and since December 14, 2023 it has been part of Veranex, a contract research organization focused on medical devices and diagnostics.Species and modelsLarge animal models are the centre of the offering: swine, both farm breeds and minipigs, sheep, cattle and goats, with mice, rats, rabbits and guinea pigs available for smaller-scale work.

Taconic Biosciences supplies the animals that other laboratories run studies in.Model supply and custom model generationCustom models are generated by gene editing, embryonic stem cell targeting and pronuclear injection, with a doctoral-level project manager assigned to each programme, and the company states it has produced roughly 5,000 custom models over the last fifteen years.

TD2, which stands for Translational Drug Development, is an oncology-focused organization in Scottsdale, Arizona.In vivo oncology modelsThe preclinical offering covers in vivo tumor models including syngeneic models, patient-derived xenografts, cell line-derived xenografts and humanized mouse models, run in a facility the company describes as AAALAC accredited.

Texas Biomedical Research Institute is an independent nonprofit research institute in San Antonio, Texas, founded in 1941 and operating from a single 200-acre campus with more than 360 staff.Key capabilitiesSee the company profile for available services and project-specific capabilities.

Translucence Biosystems, Inc. is a tissue clearing and whole-brain imaging company in Irvine, California, founded in 2018 as a spin-out of the Sunil Gandhi laboratory at the University of California, Irvine.What is sold as a productThe product line covers the Mesoscale Imaging System, described as a modified light-sheet microscope built on a ZEISS platform; Stitchy, an image stitching software tool; and three tissue clearing kits priced between about 895 and 995 US dollars.

TransPharm Preclinical Solutions, Inc. is a small infectious disease specialist in Jackson, Michigan.In vivo infection models and in vitro microbiologyThe company runs efficacy models of infection in mice and rats, with pharmacokinetic blood sampling available alongside the efficacy readouts.

Yecuris supplies liver-humanized mice and human hepatocytes from a facility in the Portland area of Oregon, and runs studies on that platform.FRG KO liver-humanized miceThe FRG designation refers to a triple knockout of Fah, Rag2 and Il2rg on a C57BL/6 background, which the company states was originally reported by Azuma and colleagues in 2007.