Nonclinical Efficacy Testing » Non-Clinical CROs and Agencies » YAKUKENSHA CO.,LTD.

YAKUKENSHA CO.,LTD.

Table of Contents
Table of Contents

YAKUKENSHA CO.,LTD. provides a broad portfolio of testing services, including blood and urine testing, toxicity studies, and safety pharmacology studies. This section introduces the characteristics of YAKUKENSHA’s nonclinical studies, presents an example disease model, and outlines case studies. This information is provided as a reference when selecting a vendor/CRO for nonclinical studies.

Nonclinical Studies Undertaken by YAKUKENSHA CO.,LTD.

YAKUKENSHA CO.,LTD. provides contract nonclinical study services with a particular emphasis on drug discovery support and safety studies. Specifically, the company conducts toxicity studies, safety pharmacology studies, and pharmacodynamic/efficacy studies using genetically engineered animals. These studies are primarily used during the drug development stage, and YAKUKENSHA also supports evaluations of medical devices and biopharmaceuticals.

YAKUKENSHA CO.,LTD. also employs CRISPR/Cas9 technology to generate genetically engineered mice and perform phenotypic analysis, supporting research in psychiatric and neurologic disorders and allergic diseases. These services contribute to studies using models of Alzheimer’s disease and atopic dermatitis, among others.

Reference: YAKUKENSHA CO.,LTD. official https://www.yakukensha.co.jp/jtk/det.php?i=1235

Contract Research Partners Offered Through YAKUKENSHA CO.,LTD.

SetsuroTech Inc.

Provides phenotypic analysis services for generated mice on a contract basis. Capabilities include assays for oxidative stress markers in blood, cytokine detection, and pharmacology/efficacy studies. The company also supports breeding, husbandry, and colony expansion for mouse production.

TRANS GENIC INC.

Provides nonclinical testing services utilizing advanced genetically engineered mice. Disease-model lines established and characterized at universities and research institutes are available under license. Disease-specific models include APPosk-Tg mice for Alzheimer’s disease research, ProBDNF KI mice for psychiatric and neurologic disorders, SJLB mice for dementia research, and IL33 Tg mice for atopic dermatitis research.

Takara Bio Inc.

Through a collaboration with Mediford Corporation, provides GLP-compliant safety studies specifically for regenerative medicine products. Services include single-dose toxicity studies tailored to product characteristics, repeated-dose toxicity studies, and in vivo and in vitro tumorigenicity studies. Leveraging extensive experience in gene therapy and cellular medicine, support is available from early research and development through clinical application.

Non-clinical case studies of YAKUKENSHA CO.,LTD.

No case studies are currently listed on the official website.

YAKUKENSHA CO.,LTD. Company Information

YAKUKENSHA CO.,LTD. is a distributor of research equipment, reagents, and consumables, primarily in the life science field. Contributing to research, it also provides online sales and contract services for equipment and technology. It provides products and services that meet the needs of companies and research institutions in a wide range of fields, including pharmaceuticals, chemistry, and biotechnology.

Address 3-12-6 Suehiro, Chuo-ku, Chiba-shi, Chiba, Japan
Tel 043-265-4141
Website https://www.yakukensha.co.jp/

3 Recommended Contract Research Organizations
for Non-Clinical Studies
— by Target goal and Expertise

In non-clinical development, the choice of contract research organization shapes the quality of the data and the time it takes to reach the next decision. Below, three CROs are introduced by the type of study they support: pharmacology (efficacy) studies, safety studies, and pharmacokinetic (PK/PD) studies. Each summary describes the services the company offers so that you can match a provider to your target and development objective.

Pharmacology (Efficacy) StudiesDisease-Relevant Models for
Translational Drug Evaluation
SMC Laboratories, Inc.
Reference: SMC Laboratories, Inc. official website (https://www.smccro-lab.com/)

SMC Laboratories, Inc.

SMC Laboratories is a specialized non-clinical CRO focused on in vivo pharmacology and efficacy studies using disease-relevant animal models, particularly in fibrosis, inflammation, metabolic diseases, and oncology.

Areas of Expertise
Disease-Relevant Model Portfolio

SMC Laboratories offers models covering the liver, lung, kidney, intestine, and oncology. Its portfolio includes the proprietary STAM™ model for MASH, fibrosis, and hepatocellular carcinoma.

Study Design Based on Target Biology

Study plans are developed around the target biology, mechanism of action, disease stage, and development objective. Pharmacological endpoints can be combined with histopathology, biomarkers, and disease-specific readouts.

Support from Target Validation to Proof of Concept

With experience from more than 1,000 studies for clients in 30 countries, SMC Laboratories supports programs from target validation and candidate selection through in vivo proof-of-concept studies.

Safety StudiesComprehensive Safety Assessment for
Preclinical Development
Charles River Laboratories
Reference: Charles River Laboratories official website (https://www.criver.com/)

Charles River Laboratories

Charles River provides non-clinical toxicology and safety assessment services for programs ranging from exploratory safety studies to IND-enabling development.

Areas of Expertise
General Toxicology Across Study Designs

Services include single- and repeat-dose toxicology, dose-range finding, and general toxicology studies across multiple species and administration routes.

Non-GLP and GLP Study Support

Charles River supports both non-GLP and GLP studies, allowing sponsors to progress from early safety characterization to studies intended for regulatory submissions.

Integrated IND-Enabling Safety Assessment

Toxicology studies can be integrated with toxicokinetics, clinical pathology, histopathology, and safety pharmacology to support interpretation and IND-enabling safety packages.

Pharmacokinetic (PK/PD) StudiesConnecting Drug Exposure with
Pharmacological Response
Inotiv
Reference: Inotiv official website (https://www.inotiv.com/)

Inotiv

Inotiv provides integrated PK/PD, DMPK, and bioanalytical services to characterize drug exposure and its relationship with pharmacological response.

Areas of Expertise
Pharmacokinetic Characterization

PK studies characterize exposure, half-life, clearance, and other pharmacokinetic parameters needed to understand how a candidate behaves in the selected model.

Exposure–Response Evaluation

Pharmacokinetic data can be combined with pharmacodynamic endpoints and bioanalysis to evaluate the relationship between drug exposure and pharmacological response.

Integrated DMPK and Development Support

Integrated DMPK, pharmacology, and safety information supports candidate comparison, dose selection, dosing-frequency optimization, and decisions about subsequent preclinical development.

By Therapeutic Area
Disease Animal Models
and Reviews
Proven Capability, Expertise and Track Record
Top 3 Non-Clinical CRO Services