A site where you can find recommended contractors for non-clinical testing｜effical " Non-Clinical CROs and Agencies " YAKUKENSHA CO.,LTD.

YAKUKENSHA CO.,LTD.

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YAKUKENSHA CO.,LTD. provides a broad portfolio of testing services, including blood and urine testing, toxicity studies, and safety pharmacology studies. This section introduces the characteristics of YAKUKENSHA’s nonclinical studies, presents an example disease model, and outlines case studies. This information is provided as a reference when selecting a vendor/CRO for nonclinical studies.

Nonclinical Studies Undertaken by YAKUKENSHA CO.,LTD.

YAKUKENSHA CO.,LTD. provides contract nonclinical study services with a particular emphasis on drug discovery support and safety studies. Specifically, the company conducts toxicity studies, safety pharmacology studies, and pharmacodynamic/efficacy studies using genetically engineered animals. These studies are primarily used during the drug development stage, and YAKUKENSHA also supports evaluations of medical devices and biopharmaceuticals.

YAKUKENSHA CO.,LTD. also employs CRISPR/Cas9 technology to generate genetically engineered mice and perform phenotypic analysis, supporting research in psychiatric and neurologic disorders and allergic diseases. These services contribute to studies using models of Alzheimer’s disease and atopic dermatitis, among others.

Reference: YAKUKENSHA CO.,LTD. official https://www.yakukensha.co.jp/jtk/det.php?i=1235

3 Specialized Pre-clinical CROs for Advanced Drug Discovery

Contract Research Partners Offered Through YAKUKENSHA CO.,LTD.

SetsuroTech Inc.

Provides phenotypic analysis services for generated mice on a contract basis. Capabilities include assays for oxidative stress markers in blood, cytokine detection, and pharmacology/efficacy studies. The company also supports breeding, husbandry, and colony expansion for mouse production.

TRANS GENIC INC.

Provides nonclinical testing services utilizing advanced genetically engineered mice. Disease-model lines established and characterized at universities and research institutes are available under license. Disease-specific models include APPosk-Tg mice for Alzheimer’s disease research, ProBDNF KI mice for psychiatric and neurologic disorders, SJLB mice for dementia research, and IL33 Tg mice for atopic dermatitis research.

Takara Bio Inc.

Through a collaboration with Mediford Corporation, provides GLP-compliant safety studies specifically for regenerative medicine products. Services include single-dose toxicity studies tailored to product characteristics, repeated-dose toxicity studies, and in vivo and in vitro tumorigenicity studies. Leveraging extensive experience in gene therapy and cellular medicine, support is available from early research and development through clinical application.

Non-clinical case studies of YAKUKENSHA CO.,LTD.

No case studies are currently listed on the official website.

YAKUKENSHA CO.,LTD. Company Information

YAKUKENSHA CO.,LTD. is a distributor of research equipment, reagents, and consumables, primarily in the life science field. Contributing to research, it also provides online sales and contract services for equipment and technology. It provides products and services that meet the needs of companies and research institutions in a wide range of fields, including pharmaceuticals, chemistry, and biotechnology.

Address	3-12-6 Suehiro, Chuo-ku, Chiba-shi, Chiba, Japan
Tel	043-265-4141
Website	https://www.yakukensha.co.jp/

3 Recommended Contract Research Organizations for Non-Clinical Studies
— by Target goal and Expertise

In drug discovery, the quality and efficiency of non-clinical studies have a direct impact on clinical success rates, development costs, and overall length of time required in R&D. In recent years, there has been more demand for clinically relevant data, globally accepted reliability, and accurate early-stage screening. Thus, it is more important than ever to select the right CRO (Contract Research Organization) for strategic approach.
In this article, we highlight three CROs with proven technical capabilities, expertise, and long standing track records. These are our TOP 3 choices based on their capabilities and the specific target goals of the researchers for their non-clinical studies.

Pharmacology (Efficacy) Studies
Replicate unknown pathological models and
Discovery to clinically oriented drug evaluation

SMC Laboratories, Inc.

Reference: SMC Laboratories, Inc. official website (https://www.smccro-lab.com/jp/)

SMC Laboratories, Inc. has established a disease models using patented mouse technologies. The company has established proprietary pathological models—particularly in liver disease and fibrosis—and continues to expand their approach across a wide range of models in cancer, inflammation, and metabolic diseases.
From exploratory research to clinically oriented efficacy evaluation, SMC offers customized study designs, dosing strategies, and evaluation analysis tailored to each project. Their collaborative approachallows researchers to discuss and refine study plans together with SMC’s expert scientists.
With flexible small-scale study options and strong technical support, SMC Laboratories, Inc. is an ideal partner for start-ups, biotech ventures, and academic institutions alike.

Consult study design and disease model development
with SMC Laboratories, Inc.

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Safety Studies
Comprehensive Safety Evaluation for FIH Applications

Labcorp Holdings Inc.
(Labcorp Drug Development)

Reference: Labcorp Holdings Inc. official website (https://jp.labcorp.com/)

Labcorp Holdings Inc. provides a fully integrated GLP testing system aligned with international regulatory standards, including FDA, EMA, and PMDA requirements. All studies are conducted under ICH-compliant quality assurance, making it ready for data submission.
The company has extensive expertise in long-term toxicity studies such as Segment I–III reproductive and carcinogenicity studies, as well as 2-year chronic toxicity assessments.
Labcorp Holdings Inc.’s comprehensive approach enables sponsors to efficiently outsource the entire preclinical package from toxicology, toxicokinetic (TK), and safety pharmacology study design to execution. This accelerates a path to First-in-Human (FIH) trials. For most of the global drug developers, this all-in-one service structure minimizes cost, risk, and expedite the time before advancing to clinical phase.

Consult Labcorp Holdings Inc.
Discuss GLP/ICH-compliant study design for your FIH submission.

To labcorp.
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Pharmacokinetic (PK/PD) Studies
High-Precision Bioanalysis for Clinically Predictive PK/PD Evaluation

PhoenixBio Co., Ltd.

Source: PhoenixBio Co., Ltd. Official Website (https://phoenixbio.co.jp/)

PhoenixBio Co., Ltd.offers pharmacokinetic and hepatic metabolism studies using their proprietary PXB-mouse®, a humanized-liver chimeric mouse model. This platform enables the acquisition of data with high clinical correlation in ADME, drug–to-drug interaction studies, bridging the gap between preclinical and clinical stages.
With advanced LC-MS/MS-based bioanalysis, PhoenixBio Co., Ltd. provides aseamless workflow from plasma concentration measurement and metabolite identification to quantitative validation.
The company offersan integrated evaluation analysiscovering pharmacokinetics, hepatotoxicity, and safety with flexibility to accommodate complex modalities such as oligonucleotide and middle-molecule therapeutics. For compounds where hepatic metabolism is a development bottleneck—or where quantitative, reproducible exposure data are critical—PhoenixBio Co., Ltd. delivers unmatched analytical precision and consistency.

Consult Phoenix Bio for PK/PD analysis with a clinical focus

Phoenix Bio.
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