YAKUKENSHA CO.,LTD. provides a broad portfolio of testing services, including blood and urine testing, toxicity studies, and safety pharmacology studies. This section introduces the characteristics of YAKUKENSHA’s nonclinical studies, presents an example disease model, and outlines case studies. This information is provided as a reference when selecting a vendor/CRO for nonclinical studies.
YAKUKENSHA CO.,LTD. provides contract nonclinical study services with a particular emphasis on drug discovery support and safety studies. Specifically, the company conducts toxicity studies, safety pharmacology studies, and pharmacodynamic/efficacy studies using genetically engineered animals. These studies are primarily used during the drug development stage, and YAKUKENSHA also supports evaluations of medical devices and biopharmaceuticals.
YAKUKENSHA CO.,LTD. also employs CRISPR/Cas9 technology to generate genetically engineered mice and perform phenotypic analysis, supporting research in psychiatric and neurologic disorders and allergic diseases. These services contribute to studies using models of Alzheimer’s disease and atopic dermatitis, among others.
Provides phenotypic analysis services for generated mice on a contract basis. Capabilities include assays for oxidative stress markers in blood, cytokine detection, and pharmacology/efficacy studies. The company also supports breeding, husbandry, and colony expansion for mouse production.
Provides nonclinical testing services utilizing advanced genetically engineered mice. Disease-model lines established and characterized at universities and research institutes are available under license. Disease-specific models include APPosk-Tg mice for Alzheimer’s disease research, ProBDNF KI mice for psychiatric and neurologic disorders, SJLB mice for dementia research, and IL33 Tg mice for atopic dermatitis research.
Through a collaboration with Mediford Corporation, provides GLP-compliant safety studies specifically for regenerative medicine products. Services include single-dose toxicity studies tailored to product characteristics, repeated-dose toxicity studies, and in vivo and in vitro tumorigenicity studies. Leveraging extensive experience in gene therapy and cellular medicine, support is available from early research and development through clinical application.
No case studies are currently listed on the official website.
YAKUKENSHA CO.,LTD. is a distributor of research equipment, reagents, and consumables, primarily in the life science field. Contributing to research, it also provides online sales and contract services for equipment and technology. It provides products and services that meet the needs of companies and research institutions in a wide range of fields, including pharmaceuticals, chemistry, and biotechnology.
| Address | 3-12-6 Suehiro, Chuo-ku, Chiba-shi, Chiba, Japan |
|---|---|
| Tel | 043-265-4141 |
| Website | https://www.yakukensha.co.jp/ |
In non-clinical development, the choice of contract research organization shapes the quality of the data and the time it takes to reach the next decision. Below, three CROs are introduced by the type of study they support: pharmacology (efficacy) studies, safety studies, and pharmacokinetic (PK/PD) studies. Each summary describes the services the company offers so that you can match a provider to your target and development objective.
SMC Laboratories is a specialized non-clinical CRO focused on in vivo pharmacology and efficacy studies using disease-relevant animal models, particularly in fibrosis, inflammation, metabolic diseases, and oncology.
SMC Laboratories offers models covering the liver, lung, kidney, intestine, and oncology. Its portfolio includes the proprietary STAM™ model for MASH, fibrosis, and hepatocellular carcinoma.
Study plans are developed around the target biology, mechanism of action, disease stage, and development objective. Pharmacological endpoints can be combined with histopathology, biomarkers, and disease-specific readouts.
With experience from more than 1,000 studies for clients in 30 countries, SMC Laboratories supports programs from target validation and candidate selection through in vivo proof-of-concept studies.
Charles River provides non-clinical toxicology and safety assessment services for programs ranging from exploratory safety studies to IND-enabling development.
Services include single- and repeat-dose toxicology, dose-range finding, and general toxicology studies across multiple species and administration routes.
Charles River supports both non-GLP and GLP studies, allowing sponsors to progress from early safety characterization to studies intended for regulatory submissions.
Toxicology studies can be integrated with toxicokinetics, clinical pathology, histopathology, and safety pharmacology to support interpretation and IND-enabling safety packages.
Inotiv provides integrated PK/PD, DMPK, and bioanalytical services to characterize drug exposure and its relationship with pharmacological response.
PK studies characterize exposure, half-life, clearance, and other pharmacokinetic parameters needed to understand how a candidate behaves in the selected model.
Pharmacokinetic data can be combined with pharmacodynamic endpoints and bioanalysis to evaluate the relationship between drug exposure and pharmacological response.
Integrated DMPK, pharmacology, and safety information supports candidate comparison, dose selection, dosing-frequency optimization, and decisions about subsequent preclinical development.