Mediford Corporation

Mediford offers a comprehensive range of non-clinical research services, including various safety studies required for regulatory submissions, pharmacology and pharmacokinetics studies. This page provides an overview of the key features of Mediford’s non-clinical service capabilities, examples of disease models, and representative study cases. It is intended to serve as a reference for selecting a CRO.

Features of Mediford’s Contract Non-Clinical Research Services

Extensive Study Portfolio

Mediford provides a wide variety of non-clinical studies, including pharmacology, safety, and pharmacokinetics studies. The company offers end-to-end support—from exploratory screening and new modality evaluation to transition into clinical development and regulatory submission. They offer flexible and efficient study execution with their dedicated project management system.

Highly Qualified Specialists

Mediford has JSTP/ JCVP-certified specialists in toxicology and pathology, as well as veterinarians, pharmacists, laboratory animal technologists, and JSOT-certified toxicologists. Their expertise enables high-quality data generation and supports establishing new evaluation protocols for emerging modalities and novel therapeutic concepts.

Commitment to Animal Welfare

All studies follow the 3Rs (Replacement, Reduction, Refinement) principles. Mediford implements microsampling techniques to analyze drug concentrations with minimal blood volume, reducing the number of animals required. The company is fully cerfitied by AAALAC International.

Infectious Disease Model Development and Evaluation

With ABSL2 and BSL2 facilities, Mediford conducts the full spectrum of infectious disease studies—from establishing a new model with viruses, bacteria, and fungi to efficacy and vaccine evaluation. Experienced researchers will deliver timely and reliable data to support your needs.

Examples of Disease Models Offered by Mediford

It is essential to go through the testing of candidate compounds in animal models that reproduce the target disease before advancing to clinical trials.

However, clinically relevant disease models may not always exist, thus there are demands for animal models with strong clinical correlation.

Below are some examples of disease models offered at Ina Research.

LPS-Induced Depression Model

A depression model is induced by administering lipopolysaccharide (LPS) to mice. Antidepressant effects can be evaluated by behavioral tests(forced swim, tail suspension, where immobility time serves as an indicator.)

Post-Stroke Pain Model

Post-stroke central pain is a persistent and debilitating complication of stroke. In this model, collagenase IV is microinjected into the ventral posterolateral nucleus of the thalamus in SD rats to induce intracerebral hemorrhage and reproduce CPSP pathology.

PDX Model (Oncology)

The PDX (Patient-Derived Xenograft) model is established by transplanting patient-derived tumor tissue into immunodeficient mice. Because tumor characteristics such as genetic mutations and microenvironment are preserved, PDX models are widely used in efficacy testing of anticancer and molecular-targeted therapies, as well as personalized medical research.

Ischemic Heart Disease Model

Myocardial infarction models in rats and mice are created by temporarily occluding and reopening the coronary artery to reproduce ischemia–reperfusion injury. Cardiac function is assessed using high-resolution ultrasound imaging (Vevo F2), allowing non-invasive analysis of left ventricular ejection fraction and wall motion.

GVHD Model

The graft-versus-host disease (GVHD) model reproduces the pathology in which donor immune cells attack host tissues after hematopoietic stem cell transplantation. The model is widely used to evaluate immunosuppressants and cell-based therapies.

Mediford’s Non-Clinical Study Examples

Neuropathic Pain Model Development

Neuropathic pain is a chronic condition caused by peripheral or central nerve injury. Mediford has extensive experience with the Bennett (thermal, mechanical, cold stimuli), Chung (thermal, mechanical), and Seltzer (thermal, mechanical) models, enabling reliable and reproducible pharmacology studies.

Skin Permeability Test in Compliance with GLP for Pesticides

In vitro skin permeability studies evaluate the penetration and transdermal transfer of test substances using human or animal skin. When combined with in vivo rat dermal administration studies, human in vivo absorption rates can also be estimated. Study results required for pesticide registration, including re-evaluation, are generated under pesticide GLP standards.

Company Information

Mediford provides medical writing services and contract research services, which utilize wide range of pathological models. They have decades of experience in non-clinical research.