EAE (MOG-induced)
This article explains the "EAE (MOG-induced)" model, which is widely used in research and new drug development for multiple sclerosis (MS). We will summarize its characteristics, main uses, research subjects, and key products.
EAE (MOG-induced)
EAE isPathological model widely used to study multiple sclerosis (MS)In this model, immune cells are activated by injecting mice with MOG (myelin oligodendrocyte glycoprotein) peptide along with an immunostimulant. This causes the immune cells to attack their own nerves (myelin) and induce inflammation.
By using the EAE model,Clarifying the pathological mechanisms of multiple sclerosis, and evaluating the efficacy of new immunotherapies and anti-inflammatory drugs.This will be possible.
The main subjects of research utilization
| Diseases for research |
How to use a disease model |
| Multiple Sclerosis (MS) |
Used for efficacy evaluation of new therapeutic agents and confirmation of neuroprotective effects |
| Optic neuritis |
To elucidate the mechanism of vision loss caused by inflammation and demyelination of the optic nerve, which is often associated with MS, and to evaluate drug efficacy for symptom relief. |
EAE models are primarilyEvaluation of Novel Therapeutics for Central Nervous System Autoimmune Diseases Such as Multiple SclerosisIt is widely used. It is also widely used in basic research, such as elucidating the mechanisms by which autoreactive T cells cause inflammation and demyelination, and exploring new therapeutic targets.
| How to use |
Details |
| Clinical scoring |
Quantitatively evaluate motor impairments such as reduced tail tension, hindlimb paralysis, and complete quadriplegia through daily scoring. |
| Histopathological analysis |
Create sections of the spinal cord and brain to evaluate the degree of inflammatory cell infiltration and demyelinated areas of myelin (myelin sheath). |
| Immunological analysis |
Measuring the dynamics of T cells, macrophages, etc. in the central nervous system and lymph nodes |
EAE (MOG-induced) review
Demonstration of establishing a multiple sclerosis model using MOG peptide
In this paper,Confirmation of response to multiple sclerosis (MS)In the study, synthetic MOG peptide injections into H-2b mice (e.g., C57BL/6J) induced T cell responses similar to multiple sclerosis, causing severe and chronic neuropathology, including ascending paralysis.
Pathology varies depending on the mouse strain, indicating the importance of epitope specificity and self-reactive T cells in disease induction.
EAE (MOG-induced) Main Products
Here, we introduce two products from the top 10 Google search results for "EAE (MOG induction) products," specifically those on which product pages could be confirmed, listed in order of search ranking (as of June 4, 2026).
Multiple Sclerosis (EAE) Mouse Model
This is an autoimmune disease mouse model developed by Biosyngen for preclinical multiple sclerosis research.
| Manufacturer/Distributor |
Analysis items |
Primary Endpoint |
| BioSiteGen Japan Co., Ltd. |
Weight measurement, clinical scores (motor function such as paralysis), and histopathological analysis (cellular infiltration by H&E staining, etc.) |
Improvement (decrease) in clinical score, suppression of weight loss, and reduction in infiltration of inflammatory cells and demyelination in spinal cord tissue. |
Hooke Kit MOG35-55CFA Emulsion PTX
This kit is provided for efficient induction of EAE in mice. It includes an emulsion pre-mixed with MOG35-55 antigen and complete Freund's adjuvant (CFA), along with pertussis toxin (PTX).
| Manufacturer/Distributor |
Analysis items |
Primary Endpoint |
Manufacturer: Hooke Laboratories, Inc.
Distributor: Cosmo Bio Co., Ltd. |
Clinical scores (decreased tail tone and hindlimb paralysis), body weight changes, histopathological assessment of central nervous system tissue, and immunological analysis |
Confirmation of EAE incidence, degree of motor dysfunction, lesion formation in the spinal cord |
Summary
This article introduced information on the EAE (MOG-induced) model, which is used in multiple sclerosis research and new drug development.When conducting non-clinical studies, reliable model selection is important.This can be said. This site introduces pathological models used in preclinical studies, so please refer to the following articles as well.
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