Nihon Bioresearch Inc.

Nihon Bioresearch Inc. is a contract research organization specializing in pharmacological efficacy studies and the development of numerous disease models. This page provides an overview of the company’s non-clinical study capabilities, examples of disease models, and selected study cases. Please use this information as a reference when selecting a CRO for non-clinical studies.

Features of Nihon Bioresearch Inc.’s Non-clinical Contract Services

Extensive Disease Models and Animal Species

Nihon Bioresearch Inc. has developed more than 300 disease models and evaluation studies are available across a wide range of areas, including pharmaceuticals, medical devices, regenerative medicine products, and functional foods.
The company offers study models with high translational correlation to humans, enabling accurate evaluation and supporting drug discovery and development. With various animal species, Nihon Bioresearch provides assessments based on a broad array of pathophysiological models in central nervous, metabolic, inflammation, and other indications.

Studies Using Miniature Pigs

The company provides a wide range of non-clinical studies using miniature pigs. It is conducted at a specialized GLP-compliant facility that can house up to 178 animals.
Miniature pigs, known for their strong translational correlation to humans, are used for pharmacology, pharmacokinetics, and safety studies in the cardiovascular, urological, allergic, and metabolic indications.

Comprehensive Evaluation of Central Nervous System Disorders

Nihon Bioresearch Inc. offers tailored CNS studies using multiple small-animal models for evaluating dementia, Parkinson’s disease, depression, anxiety, and related disorders. The company has focused particularly on developing cognitive impairment models such as the rotenone intranigral injection Parkinson’s model and the single intracerebroventricular dose α-synuclein model. A wide range of CNS models—including depression/anxiety, schizophrenia, and autism—can be used for drug efficacy assessment and pathophysiological analyses.

Contract Companies Handled by Nihon Bioresearch Inc.

No partner CROs were listed.

Nihon Bioresearch Inc. Non-clinical Case Studies

Pharmacology (Efficacy) Studies

Nihon Bioresearch Inc. offers a wide selection of animal models across multiple fields (CNS, respiratory/cardiovascular, metabolic, gastrointestinal, allergic, etc.).
The company can provide proposal study design and develop new models based on client needs.
Their strengths include studies using diverse animal species and advanced CNS evaluation protocols such as PCP-induced schizophrenia models, olfactory bulbectomy–induced depression models, and behavioral/functional analyses of genetically engineered animals.

Miniature Pig Studies

The company operates a dedicated facility capable of housing up to 178 miniature pigs for both breeding and experimental use.
Its track record includes pharmacology studies for cardiovascular, urological, allergic, and metabolic indication, pharmacokinetic studies of topical formulations, skin irritation testing, and repeated-dose toxicity studies.
Nihon Bioresearch Inc. offers study proposal that account for the characteristics and human translatability of miniature pigs.

Toxicology Studies

Nihon Bioresearch Inc. conducts reproductive and developmental toxicity studies, GLP-compliant studies in miniature pigs, adverse effect confirmation study, and testing of specialized medical devices.
The company offers models with various animal species and administration routes. They have experience performing all ICH Study 1, 2, and 3 studies, including those using transdermal administration.
Furthermore, their proprietary GLP/FDA Part 11–compliant preclinical data management system ensures the delivery of highly reliable data.

Company Information

Nihon Bioresearch Inc. offers reproducible reliable contracted services with co-development and proposal driven approach for pharmaceuticals, medical devices, and regenerative medicine products.