TRANS GENIC INC. is a company whose strengths include a 40-year history, a proven track record, and technologies developed at GLP-compliant facilities. This section details the features of TRANS GENIC INC.’s nonclinical studies, provides an example of a disease model, and presents case studies. Please use this information as a reference when selecting a contract research company.
Specializes in non-clinical studies using genetically engineered mice and ratsTRANS GENIC INC. is a company whose strengths include a 40-year history, a proven track record, and technologies developed at GLP-compliant facilities. This section details the features of TRANS GENIC INC.’s nonclinical studies, provides an example of a disease model, and presents case studies. Please use this information as a reference when selecting a contract research company.
TRANS GENIC INC.offers models covering a broad range of disease areas, including the central nervous system, the cardiovascular system, and metabolic diseases, to address varied research needs.
A system is in place to support a smooth transition from nonclinical to clinical trial phases, enabling the collection and use of data from early development to advance to subsequent steps efficiently.
It is essential to go through the testing of candidate compounds in animal models that reproduce the target disease before advancing to clinical trials.
However, clinically relevant disease models may not always exist, thus there are demands for animal models with strong clinical correlation.
Below are some examples of disease models offered at Ina Research.
Mice are used as animal models that exhibit key pathological features of Parkinson’s disease. This disease model is expected to support elucidation of Parkinson’s disease mechanisms and the development of new treatment approaches.
The company maintains a rat model of cerebral infarction to facilitate the development of new treatment methods. This disease model enables evaluation of the effects of therapies and rehabilitation on a range of symptoms caused by cerebral infarction.
No case studies are currently listed on the official website.
TRANS GENIC INC. operates a drug discovery support business as well as an investment and consulting business. In drug discovery support, the company provides services spanning from the early stages of discovery through the clinical trial stage, including the creation of genetically engineered animals, nonclinical testing, and antibody production. In its investment and consulting business, the company supports clients through M&A and business restructuring.
| Address | 2-3-36 Tenjin, Chuo-ku, Fukuoka-shi, Fukuoka, Japan |
|---|---|
| Tel | 092-288-8470 |
| Website | https://www.transgenic.co.jp/ |
In non-clinical development, the choice of contract research organization shapes the quality of the data and the time it takes to reach the next decision. Below, three CROs are introduced by the type of study they support: pharmacology (efficacy) studies, safety studies, and pharmacokinetic (PK/PD) studies. Each summary describes the services the company offers so that you can match a provider to your target and development objective.
SMC Laboratories is a specialized non-clinical CRO focused on in vivo pharmacology and efficacy studies using disease-relevant animal models, particularly in fibrosis, inflammation, metabolic diseases, and oncology.
SMC Laboratories offers models covering the liver, lung, kidney, intestine, and oncology. Its portfolio includes the proprietary STAM™ model for MASH, fibrosis, and hepatocellular carcinoma.
Study plans are developed around the target biology, mechanism of action, disease stage, and development objective. Pharmacological endpoints can be combined with histopathology, biomarkers, and disease-specific readouts.
With experience from more than 1,000 studies for clients in 30 countries, SMC Laboratories supports programs from target validation and candidate selection through in vivo proof-of-concept studies.
Charles River provides non-clinical toxicology and safety assessment services for programs ranging from exploratory safety studies to IND-enabling development.
Services include single- and repeat-dose toxicology, dose-range finding, and general toxicology studies across multiple species and administration routes.
Charles River supports both non-GLP and GLP studies, allowing sponsors to progress from early safety characterization to studies intended for regulatory submissions.
Toxicology studies can be integrated with toxicokinetics, clinical pathology, histopathology, and safety pharmacology to support interpretation and IND-enabling safety packages.
Inotiv provides integrated PK/PD, DMPK, and bioanalytical services to characterize drug exposure and its relationship with pharmacological response.
PK studies characterize exposure, half-life, clearance, and other pharmacokinetic parameters needed to understand how a candidate behaves in the selected model.
Pharmacokinetic data can be combined with pharmacodynamic endpoints and bioanalysis to evaluate the relationship between drug exposure and pharmacological response.
Integrated DMPK, pharmacology, and safety information supports candidate comparison, dose selection, dosing-frequency optimization, and decisions about subsequent preclinical development.