Kamakura Techno‒Science, Inc.

Kamakura Techno‒Science, Inc. is a spin-off contract research organization(CRO) from Toray Industries’ research institution.
They are a GLP-compliant facility, the company conducts a wide range of non-clinical studies—Pharmacology(PD), Safety, and Pharmacokinetics(PK)studies—at their facilities.

Features of KamakuraTechno‒Science’s Non-clinical Services

Robust evaluation capabilities across multiple therapeutic areas

The company offers non-clinical pharmacological studies, which cover diverse disease areas. This includes Neurological, Cardiovascular, and Gastrointestinal related areas (Cerebral infarction, Diabetes, and Allergic dermatitis models). They use evaluation methods established through Toray Industries’expertise in pharmaceutical research.

Kamakura Techno‒Science, Inc. Science also provides numerous exploratory and PoC-supporting models, including L-DOPA–induced model and Pruritus model. You can expect their flexible and scientifically backed proposal for your non-clinical needs.

GLP-compliant drug safety assessment

KamakuraTechno‒Science provides non-clinical safety testing for a wide range of material, including pharmaceutical drugs, medical devices, or food additives.
The company is in compliance with GLP standards—Pharmaceutical GLP, Medical Device GLP, Chemical Substances Control Law GLP, and OECD GLP. —They offer extensive experience in general toxicity, genotoxicity, immunotoxicity, and biological safety testing.

Its capabilities also include skin sensitization/irritation testing, pyrogen testing, and other assessments required in the medical device development, delivering both regulatory compliance and high reliability.

High-precision pharmacokinetic analysis using LC/MS/MS

Using high-sensitivity LC/MS/MS platforms such as the SCIEX QTRAP® 6500, Kamakura Techno‒Science, Inc. performs high-precision drug concentration analysis for various biological materials.

The company supports both in-vitro and in-vivo pharmacokinetic assessments, including CYP inhibition/induction studies, metabolic stability studies, PK studies, and biliary excretion studies. In addition to GLP-compliant analysis, metabolite profiling and hemodialysis removal assessment are also available.
These high-quality, radioisotope-free data support accurate evaluation of drug’s safety and efficacy.

An Example Model Available at Kamakura Techno‒Science, Inc.

Neuropathic Pain Model (Chung Model)

The Chung model reproduces neuropathic pain caused by peripheral nerve injury and is widely used in evaluating analgesic drug candidates.
By ligating a portion of the sciatic nerve, mechanical allodynia and thermal hypersensitivity can be quantitatively assessed in the affected hindlimb.

Kamakura Techno-Science maintains multiple neurological disease models—including the Chung model, water-immersion stress model, and tremor model. They offer GLP-compliant testing to deliver highly reliable data.

Reference:
https://www.kamakura-ts.co.jp/test/pharmacology/index.html

Case study For a Non-clinical Study Conducted by Kamakura Techno‒Science, Inc.

Pharmacological study using a Pulmonary Fibrosis Model

The company conducts pharmacological evaluations in respiratory disease research using a well-established pulmonary fibrosis model.

Fibrosis is induced by repeated administration of bleomycin, enabling quantitative assessment of anti-fibrotic drug efficacy.
Study endpoints include lung function, histopathology, and inflammatory markers, providing comprehensive multi-angle evaluation.

GLP-compliant execution is also available, supporting clients’ drug development with reliable and reproducible data.

Reference:
https://www.kamakura-ts.co.jp/test/pharmacology/index.html

Company Information