Porsolt

Porsolt is a global CRO based in France.We provide a broad range of contract services for non-clinical development, ranging from early drug discovery screening to pharmacology, safety evaluation, pharmacokinetics, and support toward regulatory submissions.The tests are conducted not by an agency, but by our own research facility and specialized staff.

Characteristics of Porsolt's non-clinical contract testing services

Efficacy evaluation and pharmacological testing for diverse disease areas

In Porsolt,Central nervous system, cardiovascular, inflammation, oncology, pain, respiratory, liver disease, metabolic disease, skin disease, etc.We support non-clinical research across a wide range of fields. Equipped with various evaluation systems including in vitro, ex vivo, in ovo, and in vivo, we conduct pharmacological studies using multiple animal species. We can develop testing systems tailored to your research objectives, ranging from early-stage drug discovery screening to the efficacy evaluation of candidate compounds.

Safety pharmacology and non-clinical studies compliant with GLP

In the safety evaluation,Pharmacological and toxicological tests compliant with GLPare being conducted. We support studies evaluating effects on the cardiovascular, central nervous, and respiratory systems as a core battery based on ICH S7. A wide range of evaluations from in vitro to in vivo is possible, including hERG channel assays, blood pressure, heart rate, and electrocardiogram measurements, as well as respiratory function evaluations. Porsolt has continuously maintained its GLP compliance status since passing a GLP compliance audit in 2000.

Supporting drug discovery and development from pharmacokinetics to regulatory submissions

Not only efficacy evaluation,pharmacokinetic study, formulation analysis, bioanalysis, toxicity evaluationWe also offer services such as pharmacokinetics using multiple animal species including mice, rats, dogs, and minipigs, with the capability to collect samples of blood, plasma, cerebrospinal fluid, and various tissues. In addition, we provide scientific support for regulatory submissions at each stage of non-clinical development.

An example of a disease model owned by Porsolt

At Porsolt, we have developed various in vivo and in vitro models for each disease area. For example, in the oncology field,orthotopic and subcutaneous xenograft models targeting breast cancer, lung cancer, colorectal cancer, glioblastoma, etc.Supports drug efficacy evaluation using [X]. Models can be selected according to the disease and evaluation purpose.

Porsolt preclinical study cases

2D・3Dモデルを用いた予測毒性評価

The Porsolt official website publishes papers and research results related to non-clinical research. For example,A study continuously evaluating drug withdrawal in rats using telemetryNow, we are measuring body temperature, amount of exercise, heart rate, mean arterial pressure, and other parameters over time. On the other hand, case studies summarizing the contents and results of trials commissioned by individual pharmaceutical companies are limited on our official website.

Porsolt's corporate information