A site where you can find recommended contractors for non-clinical testing｜effical " Non-Clinical CROs and Agencies " EP Mediate Co.,Ltd.

EP Mediate Co.,Ltd.

Table of Contents

EP Mediate Co.,Ltd. provides non-clinical (in vivo and in vitro) functional and safety evaluations, identification of active ingredients, and studies on qualitative and quantitative analytical methods. This section introduces the features of EP MEDIATE’s non-clinical studies, examples of disease models, and related case studies. Please use this information as a reference when selecting a contract research organization (CRO) for non-clinical studies.

Features of EP Mediate Co.,Ltd.’s Non-Clinical Testing Services

Extensive Experience and Network

Since 2001, EP Mediate Co.,Ltd. has specialized in the development of health and functional foods as a food-focused CRO, accumulating extensive experience in this field. The company has conducted over 1,600 commissioned clinical trials (human studies) and approximately 800 non-clinical studies. It has worked with about 500 client companies, including overseas partners, and has established a nationwide network of medical institutions and study participants across Japan.
This network enables the evaluation of effects on humans for a wide range of products, including foods, supplements, health foods, cosmetics, exercise devices, beauty equipment, and relaxation products.

Reference: EP Mediate Co.,Ltd. official website ( https://www.ep-mediate.co.jp/business_ffc.php#01 )

Wide Range of Services

EP Mediate Co.,Ltd. provides diverse contract research services, including clinical trials (human studies) for food products, basic and animal research, and studies on functional ingredients.

Expert Suppor

With renowned experts in medicine and statistics as advisors, we provide sophisticated and precise services. Also, consulting and assistance with thesis development,Total R&D supportIt is a system that can

3 Specialized Pre-clinical CROs for Advanced Drug Discovery

Contract Research Partners Introduced by EP Mediate Co.,Ltd.

ITEC Labs

ITEC Labs conducts contract research that integrates genomics and molecular analysis, monkey model studies, in vivo efficacy and functional studies using small animals and cells, metabolomics analysis, and gut microbiota profiling.

EP Mediate Co.,Ltd.’s Non-Clinical Study Examples

Toxicology Studies

The company conducts a wide range of safety tests, including single and repeated dose toxicity tests, genotoxicity tests (Ames, chromosomal aberration, micronucleus), reproductive and developmental toxicity tests, carcinogenicity tests, and skin and eye irritation tests.

Reference: EP Mediate Co.,Ltd. official websitehttps://www.ep-mediate.co.jp/business_ffc.php

Efficacy Studies Using Disease Models

Efficacy studies are conducted using various animal disease models to evaluate blood pressure reduction, blood glucose control, body fat reduction, arthritis relief, cholesterol reduction, anti-allergy effects, anti-tumor effects, and improvement of hyperuricemia.

Reference: EP Mediate Co.,Ltd. official websitehttps://www.ep-mediate.co.jp/business_ffc.php

Other Tests

EP MEDIATE can accommodate specialized testing requests, including safety evaluations of cosmetics and topical agents, in vitro tests, efficacy screening using genetic analysis, special analyses, and repellency tests.

Reference: EP Mediate Co.,Ltd. official websitehttps://www.ep-mediate.co.jp/business_ffc.php

Company Information

EP MEDIATE is engaged in medical device development support, health food development support (food CRO), and in vitro diagnostic (IVD) development support businesses.

Address	1-8 Tsukudo-cho, Shinjuku-ku, Tokyo
Tel	Not listed
Website	https://www.ep-mediate.co.jp/

3 Recommended Contract Research Organizations for Non-Clinical Studies
— by Target goal and Expertise

In drug discovery, the quality and efficiency of non-clinical studies have a direct impact on clinical success rates, development costs, and overall length of time required in R&D. In recent years, there has been more demand for clinically relevant data, globally accepted reliability, and accurate early-stage screening. Thus, it is more important than ever to select the right CRO (Contract Research Organization) for strategic approach.
In this article, we highlight three CROs with proven technical capabilities, expertise, and long standing track records. These are our TOP 3 choices based on their capabilities and the specific target goals of the researchers for their non-clinical studies.

Pharmacology (Efficacy) Studies
Replicate unknown pathological models and
Discovery to clinically oriented drug evaluation

SMC Laboratories, Inc.

Reference: SMC Laboratories, Inc. official website (https://www.smccro-lab.com/jp/)

SMC Laboratories, Inc. has established a disease models using patented mouse technologies. The company has established proprietary pathological models—particularly in liver disease and fibrosis—and continues to expand their approach across a wide range of models in cancer, inflammation, and metabolic diseases.
From exploratory research to clinically oriented efficacy evaluation, SMC offers customized study designs, dosing strategies, and evaluation analysis tailored to each project. Their collaborative approachallows researchers to discuss and refine study plans together with SMC’s expert scientists.
With flexible small-scale study options and strong technical support, SMC Laboratories, Inc. is an ideal partner for start-ups, biotech ventures, and academic institutions alike.

Consult study design and disease model development
with SMC Laboratories, Inc.

Consult SMC Laboratories
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Safety Studies
Comprehensive Safety Evaluation for FIH Applications

Labcorp Holdings Inc.
(Labcorp Drug Development)

Reference: Labcorp Holdings Inc. official website (https://jp.labcorp.com/)

Labcorp Holdings Inc. provides a fully integrated GLP testing system aligned with international regulatory standards, including FDA, EMA, and PMDA requirements. All studies are conducted under ICH-compliant quality assurance, making it ready for data submission.
The company has extensive expertise in long-term toxicity studies such as Segment I–III reproductive and carcinogenicity studies, as well as 2-year chronic toxicity assessments.
Labcorp Holdings Inc.’s comprehensive approach enables sponsors to efficiently outsource the entire preclinical package from toxicology, toxicokinetic (TK), and safety pharmacology study design to execution. This accelerates a path to First-in-Human (FIH) trials. For most of the global drug developers, this all-in-one service structure minimizes cost, risk, and expedite the time before advancing to clinical phase.

Consult Labcorp Holdings Inc.
Discuss GLP/ICH-compliant study design for your FIH submission.

To labcorp.
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Pharmacokinetic (PK/PD) Studies
High-Precision Bioanalysis for Clinically Predictive PK/PD Evaluation

PhoenixBio Co., Ltd.

Source: PhoenixBio Co., Ltd. Official Website (https://phoenixbio.co.jp/)

PhoenixBio Co., Ltd.offers pharmacokinetic and hepatic metabolism studies using their proprietary PXB-mouse®, a humanized-liver chimeric mouse model. This platform enables the acquisition of data with high clinical correlation in ADME, drug–to-drug interaction studies, bridging the gap between preclinical and clinical stages.
With advanced LC-MS/MS-based bioanalysis, PhoenixBio Co., Ltd. provides aseamless workflow from plasma concentration measurement and metabolite identification to quantitative validation.
The company offersan integrated evaluation analysiscovering pharmacokinetics, hepatotoxicity, and safety with flexibility to accommodate complex modalities such as oligonucleotide and middle-molecule therapeutics. For compounds where hepatic metabolism is a development bottleneck—or where quantitative, reproducible exposure data are critical—PhoenixBio Co., Ltd. delivers unmatched analytical precision and consistency.

Consult Phoenix Bio for PK/PD analysis with a clinical focus

Phoenix Bio.
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