Safety Research Institute for Chemical Compounds Co., Ltd.

Established in 1970, Compound Safety Research Institute, Inc. (CSRI) has provided GLP-compliant non-clinical studies.

This page will walk you through the institute’s key features, representative disease models, and examples of their non-clinical studies.

We hope it serves as a useful reference when selecting a CRO for your non-clinical studies.

Non-Clinical Studies at Safety Research Institute for Chemical Compounds Co., Ltd.

Extensive Experience and Proven Track Record

Since 1970, CSRI has built a solid record in non-clinical testing for over 50 years. They provides high-quality safety, efficacy, pharmacology, and pharmacokinetic studies.

They have teams who are knowledgeable in both GLP and GCP regulations, which ensures each client with highly reliable data.

Comprehensive One-Stop Support system

CSRI offers seamless support from non-clinical through clinical stages, including GLP study design, execution, and submission assistance.

By handling all procedures in-house, it improves drug development efficiency and reduces overall cost through an integrated system.

Broad Scope of Services

CSRI conducts safety studies for pharmaceuticals, medical devices, regenerative medicine products, agrochemicals, and various chemical substances. their facilities are fully compliant with all GLP standards and are equipped to perform biological safety studies from Class I to Class IV.

Partnered CROs with CSRI

Hokudo Corporation

Hokudo specializes in contract non-clinical studies and antibody production.

Leveraging extensive experience and technical expertise, the company excels in pig-based pharmacological and toxicological testing and has developed rare animal models such as spinal cord injury and COPD models.

Fukushima Medical Device Development Support Center

This center conducts implantation and other non-clinical studies using large animals (swine).

They provide GLP/ non-GLP studies, and also offers training programs in medical procedures including cardiovascular and gastrointestinal systems.

Case Studies available at Safety Research Institute for Chemical Compounds Co., Ltd.

Reproductive and Developmental Toxicity Studies

Over the past five years, CSRI has completed approximately 50 GLP-compliant reproductive and developmental toxicity studies, supported by a team of Reproductive and Developmental Toxicologist.

They have also provided many studies for fertility and early embryonic development, prenatal and postnatal development, and maternal function, as well as testing compliant to OECD TG414, TG421, and TG422 guidelines.

Non-Clinical Studies Using Swine

Compared to dogs or rabbits, swine shares closer anatomical and physiological characteristics with humans, such as body size, tracheal structure, and vascular length.

CSRI offers clinically relevant biological safety studies—including device implantation—with GLP standards, led by veterinarians and teams with extensive clinical experience.

Company Information

With over 50 years of experience in non-clinical testing, CSRI operates as a GLP-compliant testing facility for both pharmaceuticals and agrochemicals.