Nonclinical Efficacy Testing » Non-Clinical CROs and Agencies » Clino Corporation

Clino Corporation

Table of Contents
Table of Contents

Clino Corporation collaborates with laboratory animal manufacturers to support non-clinical testing and evaluations using laboratory mini-pigs. This page will walk you through some of the key features of Clino Corporation’s non-clinical study capability, examples of disease models, and related case studies. It serves as a useful guide for selecting a CRO for non-clinical studies.

Non-Clinical Studies Conducted by Clino Corporation

Support for Large Animal Non-Clinical Studies

Clino Corporation specializes in non-clinical studies using large animals that enable testing under conditions similar to humans. In pharmaceutical and medical device development, large-animal testing plays an essential role in evaluating human-like reactions and device performance, which cannot be replicated in small animals such as rats or mice. While large-animal testing typically requires dedicated facilities, expert knowledge, and significantly higher cost, Clino Corporation overcomes these challenges through its nationwide coordination network, comprehensive animal management, and the supply of Micro Minipigs®. These capabilities ensure high-quality and reliable non-clinical studies.

Integrated Coordination and Animal Care Services

Leveraging its extensive domestic network, Clino Corporation provides comprehensive support in both study coordination and animal welfare before, during, and after the testing. This comprehensive one-stop service structure enables efficient and high-quality study execution while minimizing administrative tasks.

Provision of Unique Resources such as Micro Minipig®

Clino Corporation supplies the Micro Minipig®, one of the world’s smallest breeds of laboratory pigs developed in Japan. By utilizing this unique resource, the company offers non-clinical studies that closely mimic human physiology, earning strong recognition in the pharmaceutical and medical device sectors.

Partner CRO Introduced by Clino Corporation

Fuji Micra Co., Ltd.

Fuji Micra has independently developed ultra-small experimental pigs that weigh under 10 kg and measure less than 80 cm in length at six months of age—small enough to be housed in standard dog cages. Other disease models including atherosclerosis and chronic renal failure Micro Minipigs are available.

Case Studies

No case studies are currently listed on the official website.

Corporate Information

Clino originated as part of the research team within the Tohoku University Advanced Biomedical Engineering Research Organization, established in 2003 under the Ministry of Education, Culture, Sports, Science and Technology (MEXT) “Super COE” program (completed in 2008).

Address Collaboration Building, Aobayama Office, Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aoba, Aramaki Aza, Aoba-ku, Sendai, Miyagi, Japan
Tel 050-3716-5633
Website https://www.clino.org/

3 Recommended Contract Research Organizations
for Non-Clinical Studies
— by Target goal and Expertise

In non-clinical development, the choice of contract research organization shapes the quality of the data and the time it takes to reach the next decision. Below, three CROs are introduced by the type of study they support: pharmacology (efficacy) studies, safety studies, and pharmacokinetic (PK/PD) studies. Each summary describes the services the company offers so that you can match a provider to your target and development objective.

Pharmacology (Efficacy) StudiesDisease-Relevant Models for
Translational Drug Evaluation
SMC Laboratories, Inc.
Reference: SMC Laboratories, Inc. official website (https://www.smccro-lab.com/)

SMC Laboratories, Inc.

SMC Laboratories is a specialized non-clinical CRO focused on in vivo pharmacology and efficacy studies using disease-relevant animal models, particularly in fibrosis, inflammation, metabolic diseases, and oncology.

Areas of Expertise
Disease-Relevant Model Portfolio

SMC Laboratories offers models covering the liver, lung, kidney, intestine, and oncology. Its portfolio includes the proprietary STAM™ model for MASH, fibrosis, and hepatocellular carcinoma.

Study Design Based on Target Biology

Study plans are developed around the target biology, mechanism of action, disease stage, and development objective. Pharmacological endpoints can be combined with histopathology, biomarkers, and disease-specific readouts.

Support from Target Validation to Proof of Concept

With experience from more than 1,000 studies for clients in 30 countries, SMC Laboratories supports programs from target validation and candidate selection through in vivo proof-of-concept studies.

Safety StudiesComprehensive Safety Assessment for
Preclinical Development
Charles River Laboratories
Reference: Charles River Laboratories official website (https://www.criver.com/)

Charles River Laboratories

Charles River provides non-clinical toxicology and safety assessment services for programs ranging from exploratory safety studies to IND-enabling development.

Areas of Expertise
General Toxicology Across Study Designs

Services include single- and repeat-dose toxicology, dose-range finding, and general toxicology studies across multiple species and administration routes.

Non-GLP and GLP Study Support

Charles River supports both non-GLP and GLP studies, allowing sponsors to progress from early safety characterization to studies intended for regulatory submissions.

Integrated IND-Enabling Safety Assessment

Toxicology studies can be integrated with toxicokinetics, clinical pathology, histopathology, and safety pharmacology to support interpretation and IND-enabling safety packages.

Pharmacokinetic (PK/PD) StudiesConnecting Drug Exposure with
Pharmacological Response
Inotiv
Reference: Inotiv official website (https://www.inotiv.com/)

Inotiv

Inotiv provides integrated PK/PD, DMPK, and bioanalytical services to characterize drug exposure and its relationship with pharmacological response.

Areas of Expertise
Pharmacokinetic Characterization

PK studies characterize exposure, half-life, clearance, and other pharmacokinetic parameters needed to understand how a candidate behaves in the selected model.

Exposure–Response Evaluation

Pharmacokinetic data can be combined with pharmacodynamic endpoints and bioanalysis to evaluate the relationship between drug exposure and pharmacological response.

Integrated DMPK and Development Support

Integrated DMPK, pharmacology, and safety information supports candidate comparison, dose selection, dosing-frequency optimization, and decisions about subsequent preclinical development.

By Therapeutic Area
Disease Animal Models
and Reviews
Proven Capability, Expertise and Track Record
Top 3 Non-Clinical CRO Services