Hokudo Co.,Ltd.

Hokudo Co.,Ltd. provides integrated non-clinical study, from study designing to data delivery. They provide high-quality data for evaluating drug efficacy, pharmacology, and safety study.

Features of Hokudo Co.,Ltd.’s Non-Clinical Study Services

Extensive efficacy evaluation across diverse disease models and animal species

Hokudo Co.,Ltd. offers a wide range of disease models; spinal cord injury, COPD, atopic dermatitis, hair growth, pain, inflammation, diabetes, and anti-aging. They offer various animal species, rodents(rats, mice), larger animals(pigs, sheep, rabbits)—allowing study designs tailored to diverse research needs.
They offer flexible study design for complex pharmacological studies with well-integrated platform.

Comprehensive safety testing, including simulated medical device use and mutagenicity evaluation

Hokudo Co.,Ltd. provides mutagenicity assessments such as bacterial reverse mutation test and chromosomal aberration test, as well as general toxicity testing (acute, subacute, dermal corrosion, sensitization, and eye irritation).
They perform simulated use testing for medical devices such as artificial bones and joints. This offers integrated safety evaluations for both pharmaceuticals and medical devices.

Flexible testing formats, from partial outsourcing to rental laboratory services

Hokudo Co.,Ltd. accommodates flexible arrangements to meet client needs—full study outsourcing, partial contracts, where clients handle administration or surgery while Hokudo Co.,Ltd. manages husbandry, observation, or support tasks.

Their facilities are also available for rental laboratories for those who might need a specialized set-up or for surgical training purposes. They support a wide spectrum of research and development targets.

Example of Disease Model at Hokudo Co.,Ltd.

COPD (Chronic Obstructive Pulmonary Disease) Model

Hokudo Co.,Ltd. provides pharmacological study in COPD model.
This model is induced by smoking exposure or bronchitis-like inflammation. It can reproduce COPD features such as airway inflammation, alveolar destruction, and reduced lung function.

It enables multi-parameter evaluation of drug efficacy by disease progression and is applicable to in vivo screening and efficacy evaluation.
With its strong clinical correlation to human respiratory conditions, this model serves as a valuable platform for research in respiratory diseases.

Reference:
https://www.hokudo.co.jp/4-1_kobetsushiken.html

Non-clinical study examples of EPHokudo’s Non-Clinical Study Example

Evaluation of motor function using a rat spinal cord injury model

Hokudo Co.,Ltd. conducts spinal cord injury model in rats using MASCIS Impactor to create controlled injuries.

Motor function is quantitatively assessed using the BBB (Basso, Beattie, Bresnahan) score, allowing researchers to monitor neural recovery over time.
This approach supports the evaluation of potential therapeutic drugs for nervous system repair and regeneration.

Reference:
https://www.hokudo.co.jp/4-1_kobetsushiken.html

Company Information