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BioModels, LLC

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BioModels, LLC is a Waltham, Massachusetts, USA-based contract non-clinical research organization (CRO) that provides contract services that leverage its expertise and technology. This article summarizes the features of BioModels, LLC' contract non-clinical testing services, as well as examples of the company's disease state models.

Features of BioModels, LLC' contract non-clinical testing services

Conduct predictive and translational research

BioModels, LLC is a preclinical contract research organization that conducts predictive and translational research in the areas of cancer, supportive care and lung disease for biotechnology and pharmaceutical companies.

We do not simply conduct the requested study, but aim to provide high-quality data by gaining a deep understanding of the client's research objectives and goals, and by collaboratively developing a study design to achieve them.

For cancer and cancer supportive care, fibrosis, inflammation, lung disease, etc.

The company assists clients in various aspects of the research process, from the initial inquiry through the implementation of the study to the provision of data. With the support of experienced researchers, BioModels, LLC designs and implements studies to generate actionable data by combining the client's research needs with BioModels, LLC' expertise.

The company's areas of expertise include cancer and cancer supportive care, fibrosis, inflammation, and lung disease. In each of these specialized areas, the company has animal models that reproduce the pathological conditions in each disease.

Addressing challenges in the early stages of drug development

BioModels, LLC' services focus specifically on non-GLP studies. These trials specialize in efficacy studies that provide early confirmation of a drug's effectiveness, determine its potential for future development, identify drug doses and dosing schedules prior to clinical trials, and elucidate the mechanism of action.

3 Specialized Pre-clinical CROs for Advanced Drug Discovery

Examples of pathological models held by BioModels, LLC

BioModels, LLC offers a variety of preclinical models. For fibrosis, we have extensive experience with a variety of preclinical fibrosis models to capture disease mechanisms. We can evaluate the efficacy and mechanism of action of experimental materials in models such as pulmonary fibrosis, skin fibrosis, radiation fibrosis, and liver fibrosis. In cancer supportive care, models of oral mucositis, radiation-induced dermatitis, and proctitis are also available.

BioModels, LLC Non-clinical Case Studies

No specific case studies were available on the official website.

BioModels, LLC Company Information

BioModels, LLC is a Boston-based company that serves pharmaceutical, biotech, and startup companies worldwide.

Address	360 Second Avenue Waltham, MA 02451
Tel	857-228-1100
Website	https://biomodels.com

3 Recommended Contract Research Organizations for Non-Clinical Studies
— by Target goal and Expertise

In drug discovery, the quality and efficiency of non-clinical studies have a direct impact on clinical success rates, development costs, and overall length of time required in R&D. In recent years, there has been more demand for clinically relevant data, globally accepted reliability, and accurate early-stage screening. Thus, it is more important than ever to select the right CRO (Contract Research Organization) for strategic approach.
In this article, we highlight three CROs with proven technical capabilities, expertise, and long standing track records. These are our TOP 3 choices based on their capabilities and the specific target goals of the researchers for their non-clinical studies.

Pharmacology (Efficacy) Studies
Replicate unknown pathological models and
Discovery to clinically oriented drug evaluation

SMC Laboratories, Inc.

Reference: SMC Laboratories, Inc. official website (https://www.smccro-lab.com/jp/)

SMC Laboratories, Inc. has established a disease models using patented mouse technologies. The company has established proprietary pathological models—particularly in liver disease and fibrosis—and continues to expand their approach across a wide range of models in cancer, inflammation, and metabolic diseases.
From exploratory research to clinically oriented efficacy evaluation, SMC offers customized study designs, dosing strategies, and evaluation analysis tailored to each project. Their collaborative approachallows researchers to discuss and refine study plans together with SMC’s expert scientists.
With flexible small-scale study options and strong technical support, SMC Laboratories, Inc. is an ideal partner for start-ups, biotech ventures, and academic institutions alike.

Consult study design and disease model development
with SMC Laboratories, Inc.

Consult SMC Laboratories
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Safety Studies
Comprehensive Safety Evaluation for FIH Applications

Labcorp Holdings Inc.
(Labcorp Drug Development)

Reference: Labcorp Holdings Inc. official website (https://jp.labcorp.com/)

Labcorp Holdings Inc. provides a fully integrated GLP testing system aligned with international regulatory standards, including FDA, EMA, and PMDA requirements. All studies are conducted under ICH-compliant quality assurance, making it ready for data submission.
The company has extensive expertise in long-term toxicity studies such as Segment I–III reproductive and carcinogenicity studies, as well as 2-year chronic toxicity assessments.
Labcorp Holdings Inc.’s comprehensive approach enables sponsors to efficiently outsource the entire preclinical package from toxicology, toxicokinetic (TK), and safety pharmacology study design to execution. This accelerates a path to First-in-Human (FIH) trials. For most of the global drug developers, this all-in-one service structure minimizes cost, risk, and expedite the time before advancing to clinical phase.

Consult Labcorp Holdings Inc.
Discuss GLP/ICH-compliant study design for your FIH submission.

To labcorp.
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Pharmacokinetic (PK/PD) Studies
High-Precision Bioanalysis for Clinically Predictive PK/PD Evaluation

PhoenixBio Co., Ltd.

Source: PhoenixBio Co., Ltd. Official Website (https://phoenixbio.co.jp/)

PhoenixBio Co., Ltd.offers pharmacokinetic and hepatic metabolism studies using their proprietary PXB-mouse®, a humanized-liver chimeric mouse model. This platform enables the acquisition of data with high clinical correlation in ADME, drug–to-drug interaction studies, bridging the gap between preclinical and clinical stages.
With advanced LC-MS/MS-based bioanalysis, PhoenixBio Co., Ltd. provides aseamless workflow from plasma concentration measurement and metabolite identification to quantitative validation.
The company offersan integrated evaluation analysiscovering pharmacokinetics, hepatotoxicity, and safety with flexibility to accommodate complex modalities such as oligonucleotide and middle-molecule therapeutics. For compounds where hepatic metabolism is a development bottleneck—or where quantitative, reproducible exposure data are critical—PhoenixBio Co., Ltd. delivers unmatched analytical precision and consistency.

Consult Phoenix Bio for PK/PD analysis with a clinical focus

Phoenix Bio.
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