TransCure BioServices

TransCure BioServices is a France-based contract research organization (CRO) specializing in preclinical research using humanized mouse models with reconstituted human immune systems. The company maintains a strategic collaboration with PhoenixBio.
This article provides an overview of TransCure BioServices’ core strengths and its portfolio of disease models.

Features of TransCure BioServices’ Contract Services for Non-Clinical Studies

Research support focused on flexibility and transparency

TransCure BioServicessupports the development of novel therapiesby combining innovative scientific expertise with highly personalized project support. Emphasizing flexibility and transparency, the company leverages advanced mouse models to closely align preclinical studies with client-specific research objectives.

Proprietary humanized mouse models with reconstituted human immune systems

A defining strength of TransCure BioServices lies inits proprietary humanized mouse models, generated by engrafting human hematopoietic stem cells into immunodeficient mice. These models enable the evaluation of human-specific immune responses at the preclinical stage—an area that has traditionally been difficult to address using conventional animal models.

AAALAC accreditation and commitment to responsible animal research

TransCure BioServices is committed to conducting responsible and ethical preclinical research and has beenfully accredited by AAALAC International since 2022.This accreditation reflects the company’s adherence to the highest standards of animal care and use. The company applies the principles of the 3Rs (Reduction, Refinement, and Replacement), using only the minimum number of animals required to generate high-quality and predictive data, while ensuring optimal housing and experimental conditions.

In addition, its Institutional Animal Care and Use Committee (IACUC) is composed of highly qualified scientists, veterinarians, technical staff, and animal welfare specialists, ensuring animal care practices and experimental procedures that exceed regulatory requirements.

Example of Disease Models Available at TransCure bioServices

TransCure BioServices develops advanced translational humanized mouse models with functional human immune systems. By engrafting CD34+ hematopoietic cells derived from human umbilical cord blood into highly immunodeficient mice,the company provides a powerful in vivo platform for evaluating human-specific immunotherapies.The company is doing so.

In addition to these models, TransCure BioServices offers a broad range of preclinical models, including standard immunodeficient and immunocompetent mouse models, dual-humanized mouse models, and humanized liver mouse models.

TransCure BioServices Non-Clinical Case Studies

Humanized mouse models in preclinical research on sickle cell disease

TransCure BioServices made a significant contribution to a study led by Arianna Moiani and colleagues, published in Nature Communications. In this research, humanized mouse models engrafted with CD34+ hematopoietic stem cells were used to investigate sickle cell disease (SCD),enabling a more accurate recapitulation of human disease pathology.
This innovative preclinical approach allows for more precise evaluation of therapeutic candidates targeting hemoglobinopathies and associated complications.

TransCure BioServices Company Information

TransCure BioServices is a French CRO dedicated to preclinical research using humanized mouse models. With more than 10 years of experience supporting preclinical studies across a wide range of advanced mouse models, the company possesses the scientific expertise and translational insight required to meet the complex needs of its clients.

Address	Archamps Technopole, Bâtiment de l'Alliance, 74160 Archamps, France
Tel	+33 (0)4 50 43 01 02
Website	https://www.transcurebioservices.com/