SAPPORO GENERAL PATHOLOGY LABORATORY Co.,Ltd.

SAPPORO GENERAL PATHOLOGY LABORATORY Co.,Ltd. specializes in contracted histopathological evaluation for nonclinical studies using disease models. The laboratory is recognized for detailed scoring evaluations across multiple organs and disease areas.

Features of SAPPORO GENERAL PATHOLOGY LABORATORY Co.,Ltd.’s Contract Services for Non-Clinical Studies

Specimen preparation with a broad range of staining techniques

For histopathology specimen preparation, the laboratory supports Hematoxylin and Eosin (H&E) staining, over 40 types of special stains, and immunostaining using over 200 primary antibodies. Specimens can be prepared from fixed organs and frozen blocks, and the team can provide unstained sections as well as quantitative image analysis (e.g., positive cell counts and area measurements).

The company flexibly accommodates study needs across research phases, from non-GLP to GLP studies.

Highly reliable, GLP-compliant testing framework

The laboratory has maintained a compliant (formerly “A”) rating in pharmaceutical GLP for over 30 years. Conformity evaluations have also been obtained for medical device GLP and chemical substance GLP, enabling safety and toxicity testing across a wide range of fields.

It provides highly reliable nonclinical testing services through a GLP-compliant framework and a proven track record.

From basic research to disease-model evaluation

The company receives requests from universities, pharmaceutical companies, and research institutes, and handles numerous pathology studies for basic research and pharmacology studies. Histological evaluation of disease models is also available.

Flexibility to handle small-batch requests and non-GLP studies is one of the laboratory’s strengths.

Example Disease Model at SAPPORO GENERAL PATHOLOGY LABORATORY Co.,Ltd.

NASH model / methionine- and choline-deficient (MCD) diet model

The methionine- and choline-deficient (MCD) model is one of the NASH models applied in the liver disease field. Using Hematoxylin and Eosin (H&E) staining, steatosis, lobular inflammation, and ballooning are each scored and quantified as the NAFLD Activity Score (NAS).

Fibrosis staging with Azan staining and related techniques can also be used to evaluate disease progression, including assessment up to cirrhosis. The model is highly reproducible and is commonly used in nonclinical studies for efficacy evaluation.

Reference URL: https://www.sgpl.co.jp/d_efficacy.html

Non-Clinical Case Study — SAPPORO GENERAL PATHOLOGY LABORATORY Co.,Ltd.

Histopathological evaluation across diverse disease models

The laboratory supports histopathological evaluation studies across a wide range of disease models, from kidney disease to dermatologic disease to neurodegenerative diseases.

For example, in the NASH model above, combining the NAFLD Activity Score (NAS) with the fibrosis stage enables detailed analysis of steatosis and fibrosis progression. In arthritis models, pathological findings such as bone destruction, cartilage loss, and synovial membrane thickening are graded to determine therapeutic efficacy. Quantitative evaluation using immunostaining and image analysis is also available.

See: https://www.sgpl.co.jp/d_efficacy.html

SAPPORO GENERAL PATHOLOGY LABORATORY Co.,Ltd. Company Information